Composition for promoting therapeutic effect of retina degenerative disease gene and application thereof

A retinal degeneration and composition technology, which can be used in gene therapy, drug combination, cardiovascular system diseases, etc., can solve the problem of not exerting a significant therapeutic effect, and achieve the goal of improving visual electrophysiological response, promoting functional recovery, and improving therapeutic effect. Effect
CN106344932AActive Publication Date: 2017-01-25BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Publication Date
2017-01-25

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Abstract

The invention discloses a composition for promoting a therapeutic effect of a retina degenerative disease gene and an application thereof. A research proves that the long-term C-MER proto-oncogene tyrosine kinase (MerTK) mutation can cause the serious reconstruction of a retina micro-environment, the growth arrest specific gene 6 (Gas6) necessary for MerTK exerting function is extremely reduced and the relative component of phagocytosis path is influenced, so that the joint overexpression of exogenous tyrosine kinase family receptor MerTK and ligand Gas6 is adopted for inducing retina pigment epithelial cell phagocytic ability, the retinitis pigmentosa pathology course caused by the cell phagocytic function disorder can be relieved and the theory and technical base are established for the treatment of such diseases.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and in particular relates to a composition for improving the effect of gene therapy for retinal degenerative diseases and an application thereof. Background technique

[0002] With the gradual control of optical-related eye diseases and inflammatory eye diseases, retinal neurodegenerative diseases have become the main cause of irreversible blindness in the world today, affecting the vision health of tens of millions of people. Such as retinitis pigmentosa (Retinitis Pigmentosa, RP), age-related macular degeneration (Age-related MacularDegeneration, AMD) and glaucoma. The pathological basis of visual function damage caused by such diseases is the irreversible damage of retinal neuron cells, and there is no effective treatment for this in clinic.

[0003] In recent years, the rapid progress of basic scientific research has brought new hope for the treatment of the above diseases; mainly including: gen...

Claims

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