Application of oroxylin A in preparation of inhibitor with targeting effect on AFP (alpha fetoprotein) of hepatoma cells

A technology of liver cancer cells and alpha-fetoprotein, which is applied in the field of tumor drugs, can solve the problems such as the research report on liver cancer cells without Melaleuca, and achieve the effect of good clinical value.

Inactive Publication Date: 2017-02-15
CHINA PHARM UNIV
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Problems solved by technology

[0004] At present, there is no research report on the effec

Method used

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  • Application of oroxylin A in preparation of inhibitor with targeting effect on AFP (alpha fetoprotein) of hepatoma cells
  • Application of oroxylin A in preparation of inhibitor with targeting effect on AFP (alpha fetoprotein) of hepatoma cells
  • Application of oroxylin A in preparation of inhibitor with targeting effect on AFP (alpha fetoprotein) of hepatoma cells

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Embodiment 1

[0018] In this study, an in-depth study was carried out on the anti-hepatic cancer target and mechanism of the flavonoid tumor compound celesteol. Through cell biology, biochemistry and other research methods, it was found that melaleucain can target AFP, the clinical diagnostic marker of liver cancer, down-regulate its gene and protein levels, and directly bind to AFP, inhibiting the combination of AFP and tumor suppressor protein PTEN, and then Inhibit the proliferation of liver cancer cells and induce apoptosis of liver cancer cells.

[0019] 1. Experimental materials

[0020] (1) Drugs

[0021] Melaleuca paper (C 16 h 12 o 5 , with a relative molecular weight of 284.263) was purchased from the School of Pharmacy, China Pharmaceutical University (Patent No. ZL2009 1 0029867.9), with a purity of over 99%. It was prepared as a 200mM mother solution in DMSO and stored at -20°C. Dilute to the desired concentration with serum-containing culture medium before use.

[0022] ...

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Abstract

The invention belongs to the field of tumor drugs and discloses an application of oroxylin A in preparation of an inhibitor with a targeting effect on AFP (alpha fetoprotein) of hepatoma cells. The technical scheme is the application of oroxylin A in preparation of the inhibitor with the targeting effect on AFP of the hepatoma cells. The application proves that oroxylin A can have the targeting effect on a clinical diagnostic mark AFP of hepatoma, can down-regulate protein level of AFP, is directly bound with AFP, inhibits bonding of AFP and tumor suppressor protein PTEN (phosphatase and tensin homolog), has effects of inhibiting proliferation of the hepatoma cells and inducing apoptosis of the hepatoma cells, and has better clinical value.

Description

technical field [0001] The invention belongs to the field of tumor drugs, and relates to the application of kelplin in the preparation of inhibitors targeting liver cancer cell alpha-fetoprotein. Background technique [0002] Oroxylin A is one of the active components of Scutellaria baicalensis. It has obvious antitumor effect and is a natural antitumor drug with broad application prospects. However, the pharmacological effects of kelciene are extensive, and the mechanism of its anti-tumor effect has not yet been fully elucidated. The literature shows that celestein can exert its anti-tumor effect by inducing tumor cell apoptosis, and also has the effect of inhibiting the growth of tumor blood vessels. At the same time, the anti-cancer effect of celesteol is different from that of general chemotherapy and anti-cancer drugs. It can selectively kill tumor cells and has little effect on the normal hematopoietic system, which is not available in current tumor chemotherapy drugs....

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P35/00
CPCA61K31/352A61P35/00
Inventor 郭青龙魏立彬周煜新卢娜赵丽杨林傅蓉
Owner CHINA PHARM UNIV
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