Screening method of individualized medicine and application of screening method

A screening method and drug technology, applied in the field of biomedicine, can solve problems such as hindering the development of new individualized drugs and affecting the screening of individualized drugs, achieving high commercial prospects and practical significance, improving objectivity and strong practicability.

Active Publication Date: 2017-02-15
PROTEINT (TIANJIN) BIOTECHNOLOGY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The reason why precision medicine is "precise" is that its treatment plan caters to the patient's individual cause of disease, that is, "prescribes the right medicine": while the current precision medicine attempt based on gene sequencing, due to (as menti

Method used

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  • Screening method of individualized medicine and application of screening method
  • Screening method of individualized medicine and application of screening method
  • Screening method of individualized medicine and application of screening method

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Embodiment Construction

[0064] The present invention will be further explained below in conjunction with the drawings.

[0065] Individualized drug screening and verification methods include the following steps:

[0066] (1) Construction of a molecular database of disease-related pathogenic proteins: LC / MS / MS were used to detect pathological tissue samples of a certain diseased population and corresponding tissue samples of non-diseased populations, and comparative analysis of diseased populations and non-diseased populations To find out the different protein molecules of the diseased population and the non-affected population as the molecular pathogenic factors of the disease, and establish the molecular database of the disease-related pathogenic protein;

[0067] (2) The establishment of a database of individualized clinical symptoms of patients-protein pathogenic factor response characteristics: analyze the differences in the characteristics of protein molecular pathogenic factors within the patient popu...

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Abstract

The invention provides a screening method of individualized medicine. The method includes: building a disease-related pathogenic protein molecule database, building a paint individual clinical disease course symptom-protein pathogenic factor response feature relevance database, building a disease model target medicine-protein response relevance database, and acquiring a medicine screen result. The screening method has the advantages that the method is brand new and pioneering and used for individualized precise medical treatment, genetic and environment pathogenic factors and patient disease course features can be accurately and comprehensively reflected in the detecting and analyzing result of protein molecules, and objective, precise and individualized treatment medicine applicable to different patient disease course features is screened according to the target medicine's correction of the pathogenic protein molecules.

Description

Technical field [0001] The present invention belongs to the field of biomedicine, and particularly relates to a drug screening method based on protein analysis. It also relates to the method that allows different disease characteristics of different patients to establish a one-to-one correspondence with different drugs, so that the development and use of new individualized drugs are evidence-based Kei, promote precision medicine. Background technique [0002] The basis of precision medicine is individualized etiology analysis: precision medicine is the precise measurement and interpretation of various individualized pathogenic factors (genetics and environment) of patients, which are reflected at the molecular level, and then formulated with individualized molecular disease The factor is targeted, targeted and individualized treatment. [0003] The best analysis method for individualized molecular pathogenic factors is protein analysis: the essence of precision medicine is to coll...

Claims

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88
Inventor 李捷
Owner PROTEINT (TIANJIN) BIOTECHNOLOGY CO LTD
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