Benzophenone derivatives serving as tyrosinase activating agents and applications thereof
A technology of benzophenone and tyrosinase, which is applied in the fields of cosmetics, medicine and food chemistry, can solve the problem of rare research on tyrosinase activators, and achieve the promotion of production, good activation rate, and improvement of related effects of disease
Active Publication Date: 2017-02-22
GUANGDONG IND TECHN COLLEGE
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) foreign research on tyrosinase activators is rare
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[0017] Example: Use of benzophenone derivatives as tyrosinase activators:
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Abstract
The invention belongs to the technical field of cosmetics, medicines and food chemistry, and discloses benzophenone derivatives serving as tyrosinase activating agents and applications thereof. The benzophenone derivatives serve as the tyrosinase activating agents and are one or more than one of 2-hydroxybenzophenone, 3-hydroxybenzophenone, 4-hydroxybenzophenone, 4-methoxybenzophenone, 4-aminobenzophenone, 3-aminobenzophenone, 4, 4'-dihydroxy benaophenonel, 2, 4, 4'-trihydroxybenzophenone or 3-methoxyl-4, 4'-dihydroxy benaophenonel. The compounds disclosed by the invention have intense tyrosinase activation activity and obvious application prospect in medicines (such as treatment of leucoderma) and cosmetics (such as hair-blacking liquid shampoo).
Description
technical field [0001] The invention relates to the fields of cosmetics, medicines and food chemistry, in particular to a benzophenone derivative used as a tyrosinase activator and its application in cosmetics and medicines. Background technique [0002] Tyrosinase is a multifunctional enzyme containing two copper atoms, which widely exists in microorganisms, animals, plants and the human body. This enzyme utilizes molecular oxygen to catalyze the oxidation of monophenols to diphenols (monophenolase activity) followed by the catalytic oxidation of diphenols to the corresponding quinones. Quinone undergoes a series of enzyme-catalyzed or non-enzyme-catalyzed processes to obtain mixed melanin. [0003] Tyrosinase is related to many biological processes, such as human aging and human pigmentation diseases. Recent studies have shown that the reduction of tyrosinase activity can cause people to suffer from some hypopigmentation diseases, such as: less whiteheads, vitiligo, etc....
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K8/35A61K8/41A61Q5/10A61Q19/04A61P17/00
CPCA61K8/35A61K8/41A61K31/12A61K2800/78A61Q5/10A61Q19/04
Inventor 游遨黎彧冯安生劳思敏马林邱文达张泽敏
Owner GUANGDONG IND TECHN COLLEGE
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