Composite containing anti-PD-1 gene and polycation and its application in treating cancer

A polycation and complex technology, which is applied in the field of Ming Dynasty, can solve problems such as affecting normal distribution, and achieve the effect of realizing immunotherapy and improving transfection effect.
CN106434754AInactive Publication Date: 2017-02-22SHANGHAI YUNSHUN BIOTECH
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Patent Information

Authority / Receiving Office
CN Ā· China
Current Assignee / Owner
SHANGHAI YUNSHUN BIOTECH
Publication Date
2017-02-22
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

The invention relates to the technical field of cancer treatment by T cell, and particularly relates to a composite containing anti-PD-1 gene and polycation and its application in treating tumor; the composite includes poly-cationic polymer and anti PD-1 gene in the mass ratio of 1-100: 1. The composite is transfected to the T cell externally, and the secretion anti OD-1 antibody-T cell is prepared, and PD-1 antibody can be generated, thus helping to stop the PD-1 signal, effectively helping the exhausted T cell, and promoting the T cell treatment cancer of antitumor immunity response. Compared with the prior art, the secretion anti OD-1 antibody-T cell can effectively treat tumor and realize the tumor immunological therapy; besides, the composite is free from in-vivo toxicity.
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Description

technical field

[0001] The present invention relates to the technical field of tumor treatment, in particular to a compound containing anti-PD-1 gene and polycation and its application in treating tumors, in particular to a compound containing anti-PD-1 (programmed death-1) gene The nanocomplex formed with polycations is transfected into T cells in vitro to prepare self-secreting anti-PD-1 antibody-T cells, which can produce PD-1 antibodies, thereby helping to block PD-1 signaling, which can effectively help exhausted T cells Cells, a method of treating tumors with T cells that promote anti-tumor immune responses. Background technique

[0002] T lymphocytes target and kill tumor cells expressing this specific antigen. Because of its ability to target and kill tumor cells, CTL therapy has become an ideal solution for individualized tumor treatment, and has received more and more attention from immunologists internationally. But T cells are inactivated due to the production ...

Claims

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