A kind of method for preparing oxiracetam

Abstract

Belonging to the technical field of medicine, the invention in particular relates to a preparation method of oxiracetam or pharmaceutically acceptable solvates thereof. The method includes the steps of: reacting oxiracetam acid with a compound R-CH2-OH to generate a compound with a structure shown as formula (I) in the specification, wherein R is defined as the specification. The invention also relates to the compound with a structure shown as formula (I) and application thereof in preparation of oxiracetam or pharmaceutically acceptable solvates thereof. The invention also relates to the use of R-CH2-OH in preparation of oxiracetam or pharmaceutically acceptable solvates thereof.

Description

technical field

[0001] The invention belongs to the technical field of medicine, in particular to a method for preparing oxiracetam or a pharmaceutically acceptable solvate thereof. Background technique

[0002] At present, my country's aging population is increasing, and Alzheimer's disease has a lot of impact on the lives of the patient himself, the patient's family, and the surrounding population, so it is increasingly concerned by the society. Oxiracetam is a nootropic drug used to improve memory and learning functions in patients with Alzheimer's and memory impairment. The drug was synthesized in 1974 and launched in 1984, and it is still widely used clinically. A large number of documents have reported the synthesis route and process of oxiracetam. The starting materials and reaction steps used in different processes are different, but in summary, there is the problem of low total yield. In some methods, because the intermediates need to be purified by column chroma...

Examples

Embodiment Construction

[0127] Embodiments of the present invention will be described in detail below with reference to the drawings and examples, but those skilled in the art will understand that the following drawings and examples are only for illustrating the present invention, and should not be regarded as limiting the scope of the present invention. Those who do not indicate the specific conditions in the accompanying drawings and the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

technical field

[0001] The invention belongs to the technical field of medicine, in particular to a method for preparing oxiracetam or a pharmaceutically acceptable solvate thereof. Background technique

[0002] At present, my country's aging population is increasing, and Alzheimer's disease has a lot of impact on the lives of the patient himself, the patient's family, and the surrounding population, so it is increasingly concerned by the society. Oxiracetam is a nootropic drug used to improve memory and learning functions in patients with Alzheimer's and memory impairment. The drug was synthesized in 1974 and launched in 1984, and it is still widely used clinically. A large number of documents have reported the synthesis route and process of oxiracetam. The starting materials and reaction steps used in different processes are different, but in summary, there is the problem of low total yield. In some methods, because the intermediates need to be purified by column chroma...

Examples

Embodiment Construction

[0127] Embodiments of the present invention will be described in detail below with reference to the drawings and examples, but those skilled in the art will understand that the following drawings and examples are only for illustrating the present invention, and should not be regarded as limiting the scope of the present invention. Those who do not indicate the specific conditions in the accompanying drawings and the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

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