Lincomycin solid dispersion preparation and preparation method thereof

Abstract

The invention discloses a lincomycin solid dispersion preparation and a preparation method thereof, and belongs to the technical field of new veterinary drug solid dispersion formulations. The lincomycin solid dispersion preparation is prepared from, by mass, 10-50% of lincomycin, 30-50% of polyvidone, 10-50% of poloxamer and 0-50% of drug auxiliary materials. The lincomycin is prepared into a solid dispersion, and by means of the hot-melt extrusion inclusion technology, a drug carrier can be molten in a short time to uniformly wrap the drug; the prepared lincomycin solid dispersion has the advantages that the unpleasant odor of the drug raw materials is masked, the oral palatability and absorbing ability of livestock and poultry are excellent, the water solubility of the drug is high, and the biological utilization rate is high.

Description

technical field [0001] The invention belongs to the technical field of new dosage forms of veterinary drug solid dispersions, and in particular relates to a lincomycin solid dispersion preparation and a preparation method thereof. Background technique [0002] Solid dispersion refers to a dispersion system in solid form formed by highly dispersing drugs in solid carriers. The particle size of the drug in the carrier is between 0.001 and 0.1 mm, and it is mainly used to accelerate and increase the dissolution of insoluble drugs and improve their bioavailability. At present, 90% of veterinary drugs are administered in the form of dispersion, which has the advantages of simple production process, convenient packaging, transportation and use, and can reduce labor and production costs for production enterprises and breeding industries. [0003] Commonly used methods for the preparation of solid dispersions include melting method, solvent method, solvent-melting method, solvent s...

AI Technical Summary

Problems solved by technology

At present, there are mainly lincomycin suspensions, lincomycin premixes and other dosage forms in the livestock and poultry market, all of which are simple mixtures of drug raw materials and drug excipients. The main problem with these products is that they are not compatible with drinking water. After mixing, due to the low solubility of lincomycin, the drug will settle and the animals will not be able to drink enough of the drug; due to the low dosage of lincomycin in the premix, it is difficult to mix evenly and affect the use effect; there is also lincomycin Mycin palatability is poor, and there are certain defects in clinical use

[0005] There was a patent (patent number: 201310023751.0) that reported the preparation of lincomycin soluble powder. This patent used the method of heating and melting the drug to improve the water solubility and palatability of the drug, but the melting time between the drug and the carrier was longer , the shortcomings of uneven coating and difficulty in realizing mechanized production are not suitable for large-scale promotion and use. Consult relevant literature and patents in recent years. At present, there are few reports on the development and application of lincomycin solid dispersions in China. Therefore, It is very necessary to prepare a lincomycin solid dispersion preparation with good water solubility, high dissolution rate and good palatability to improve the bioavailability of the drug and expand the clinical use of the drug

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