Ginkgo biloba extract medicinal raw material

A technology of ginkgolide and ginkgolide is applied in the field of medicine to achieve the effects of protecting the function of damaged neuron cells, highlighting the pharmacological effects, and repairing the function of damaged neuron cells

Inactive Publication Date: 2017-05-31
HEBEI RUNMAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to better exert the pharmacological activity of the two types of active ingredients, reduce the clinical dosage, and further reduce the unsafety and interference caused by impurities, it is necessary to explore and find a better ratio of the two types of active ingredients! No such research has been found so far

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  • Ginkgo biloba extract medicinal raw material

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Embodiment Construction

[0021] Below in conjunction with embodiment the present invention is described in further detail:

[0022] A medicinal raw material of ginkgo ketone ester, comprising flavonoids and lactones extracted from Ginkgo biloba, flavonoids including quercetin, kaempferol, and isorhamnetin; said lactones include bilobalide, ginkgolide A, ginkgolide Ester B, ginkgolide C; the ratio of flavonoids and lactones is 1:1.

[0023] The flavonoid components and the weight / number ratio are as follows: 3-4 parts of quercetin, 5-6 parts of kaempferol, and 6-8 parts of isorhamnetin.

[0024] The components and weight ratios of the lactones are: bilobalide, 11-13 parts; ginkgolide A, 8-9 parts; ginkgolide B, 5-6 parts; ginkgolide C, 12-13 parts.

[0025] The extraction method of flavonoids comprises the following steps,

[0026] Step A1, take a certain amount of Ginkgo biloba extract and dissolve it in water, and dissolve it by ultrasonic vibration at a temperature of 55°C for 2 minutes, then perf...

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Abstract

The invention discloses a ginkgo biloba extract medicinal raw material, and belongs to the field of medicines. The ginkgo biloba extract medicinal raw material is prepared from flavone and lactone which are extracted from ginkgo, wherein the flavone is prepared from quercetin, kaempferol and isorhamnetin; the lactone is prepared from bilobalide, ginkgolide A, ginkgolide B and ginkgolide C; a proportion of the flavone to the lactone is 1 to 1. According to the ginkgo biloba extract medicinal raw material disclosed by the invention, the proportion standard of the flavone and the lactone in original ginkgo biloba extract is changed, and an optimal proportion of a medicine for scavenging free radicals and resisting platelete aggregation is determined.

Description

technical field [0001] The invention relates to a ginkgo ketone ester medicinal raw material, which belongs to the field of medicine. Background technique [0002] Ginkgo biloba extract has a wide range of pharmacological effects, and its rich total flavonoids and total ginkgo lactones are the most important material basis for it to exert such pharmacological effects. Scavenging oxygen free radicals for anti-oxidation and antagonizing platelet-activating factor (PAF) for anti-platelet aggregation are the two most prominent pharmacological effects among its numerous biological activities. Chen Jiwu, School of Life Sciences, East China Normal University, etc. used highly sensitive chemiluminescence to study "the structure-activity relationship of 11 kinds of high-purity natural flavonoids in scavenging superoxide anion (O- 2 )", and their activity The strength and weakness were sorted, and the order of their O- 2 scavenging ability was as follows: baicalin > sacrin > qu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/365C07D311/30C07D493/20C07D493/22A61P39/06A61P7/02A61P25/00A61P25/28
CPCA61K31/352A61K31/365C07D311/30C07D493/20C07D493/22A61K2300/00
Inventor 巴卫松张新徐月清
Owner HEBEI RUNMAO PHARMA CO LTD
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