Preparation technology for centella extract

A technology of Centella asiatica extract and preparation process, which is applied in the field of preparation process of Centella asiatica extract, can solve the problems of sample dead adsorption, lower transfer rate, and increase the risk of organic residual solvents, so as to avoid secondary introduction and improve The effect of clarity

Inactive Publication Date: 2017-06-20
NINGBO GREEN HEALTH PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can obtain high-purity madecassoside single product, it uses the asiaticoside extract with a weight content of 30-97% as a raw material for separation and purification, and a certain amount must be extracted from centella asiaticoside first. content of asiaticoside extract; in addition, the price of equipment used in this method for preparative high-performance liquid chromatography is relatively high, resulting in high production costs of products
[0004] In the prior art, the extraction method of Centella asiatica extract generally uses macroporous resin purification as the main separation step after extraction. However, using macroporous resin purification method, the resin needs to be treated before use, and the purification needs to be absorbed and eluted. process, long production cycle
When using a macroporous resin for purification and elution, due to physical adsorpti

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] In the present embodiment, the preparation process of Centella asiatica extract at least includes the following steps:

[0048] 1) Raw materials from Centella asiatica (the raw materials include but not limited to whole herb of Centella asiatica, crushed whole herb, crushed material, and forms obtained by further processing, such as whole herb obtained after degreasing, puffing, etc., crushed material, crushed material, etc.) direct extraction obtained by direct extraction;

[0049] 2), carry out flocculation treatment to the direct extract obtained in step 1), and filter to obtain the flocculation extract;

[0050] 3), the flocculation extract is subjected to a post-processing process to obtain Centella asiatica extract;

[0051] Other known process schemes well known to those skilled in the art may also be included.

[0052] Compared with the prior art, this solution effectively removes more than 70% of participating impurities (including impurities after secondary ...

Embodiment 2

[0054] In the present embodiment, the preparation process of Centella asiatica extract at least includes the following steps:

[0055] 1) Raw materials from Centella asiatica (the raw materials include but not limited to whole herb of Centella asiatica, crushed whole herb, crushed material, and forms obtained by further processing, such as whole herb obtained after degreasing, puffing, etc., crushed material, crushed material, etc.) directly extract the obtained direct extract and then concentrate the concentrate after concentration;

[0056] 2), performing flocculation treatment on the concentrated liquid obtained in step 1), and filtering to obtain a flocculation extract;

[0057] 3), the flocculation extract is subjected to a post-processing process to obtain Centella asiatica extract;

[0058] Other known process schemes well known to those skilled in the art may also be included.

[0059] Compared with the prior art, this solution effectively removes more than 70% of pa...

Embodiment approach

[0076] The following is a detailed implementation of the scheme of the present invention, including the following steps (all parameters below all meet the requirements of all schemes of the present invention including but not limited to the technical schemes listed in the full text, and between parameters, parameters and technical schemes are directly There is no technically unique association, which can be replaced arbitrarily within the scope according to needs):

[0077] 1. Crushing: A certain amount of centella asiatica raw materials are continuously pulverized by a pulverizer and then sieved.

[0078] 2. Extraction and one-time concentration: the raw material is charged per hour, with 73v / v% low-carbon alcohol solvent (the concentration of low-carbon alcohol solvent can also be 61v / v%, 62v / v%, 63v / v%, 64v / v%, 65v / v%, 66v / v%, 67v / v%, 68v / v%, 69v / v%, 70v / v%, 71v / v%, 72v / v%, 60v / v%, 74v / v% v%, 75v / v%, 76v / v%, 77v / v%, 78v / v%, 79v / v%, 80v / v%, 81v / v%, 82v / v%, 83v / v%, 84v / v% ...

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PUM

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Abstract

The invention discloses a preparation technology for a centella extract. The preparation technology at least comprises the following steps: 1) acquiring an extract solution from a centella raw material; 2) performing flocculation treatment on the extract solution acquired in the step 1) and filtering, thereby acquiring a flocculation extract; 3) performing subsequent treatment on the flocculation extract, thereby acquiring the centella extract. According to the scheme provided by the invention, a flocculation system is introduced into an extract solution system through a flocculation process, so that the effect of removing the electrified foreign particles can be enhanced, the pollution resulted from the secondarily introduced foreign particles is difficult to occur and the quality of the extract is increased.

Description

technical field [0001] The invention relates to a method for purifying plant active ingredients, in particular to a preparation process for Centella asiatica extract. Background technique [0002] Centella asiatica is a perennial creeping herb. Alias: Shibaque, Bengdawan, Callagrass, Gotu Kola, Cocklegrass, Coppermoss, Luodeda, etc. Born in damp wastelands, beside villages, roadsides, and ditches. The stem prostrates to the ground and takes root at the nodes. The leaves are alternate, with long petioles; the leaves are round or reniform, 2-4 cm in diameter. Centella Asiatica (L.) Urban is the dried or rooted whole plant of Centella asiatica (L.) Urban, a dicotyledon Umbelliferae. Contains a variety of α-amyresin-type triterpenes, including Asiaticoside, Thankuniside, Isothankuniside, Madecas-soside ), Brahmoside, Brah-minoside and Brahmicacid, and Madasiatic acid. Centella asiatica has many pharmacological effects: 1) Central effect: the glycosides contained therein ha...

Claims

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Application Information

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IPC IPC(8): A61K36/23
Inventor 卢国定
Owner NINGBO GREEN HEALTH PHARMACEUTICAL CO LTD
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