Near infrared fluorescence-X-ray dual mode small animal imaging equipment

Abstract

The invention discloses a near infrared fluorescence-X-ray dual mode small animal imaging equipment. The imaging equipment is composed of an excitation source, an X-ray source, an X-ray fluorescence conversion screen, a light filter, a focusing objective lens, a fluorescence detector, an object stage and a computer, wherein the wavelength of the fluorescence detector ranges from 400 nanometer to 1700 nanometer, the excitation source, the fluorescence detector, the light filter combination and the transparent object stage can be controlled through the computer, and the computer can also shoot and output images and save them. According to the near infrared fluorescence-X-ray dual mode small animal imaging equipment, objects to be imaged can be subjected to near infrared fluorescence imaging and X-ray imaging to obtain the fluorescence images, and the advantages of the two imaging modes complement each other.

Description

Technical field [0001] The invention relates to the technical field of biomedical imaging, in particular to a near-infrared fluorescence-X-ray dual-mode small animal imaging equipment. Background technique [0002] Near-infrared two-zone fluorescence (NIR-II 1000-1700 nm) greatly reduces the absorption and scattering of photons by biological tissues, and there is almost no biological autofluorescence interference. Therefore, compared with the traditional visible and near-infrared one-zone fluorescence (400- 900 nm) in vivo imaging, near-infrared two-zone fluorescence imaging has better tissue penetration depth and higher spatial resolution. The near-infrared fluorescence imaging system can perform real-time imaging and tracing in vivo, and can observe the whole process of labeled cells in the body, but it cannot distinguish the specific position of the organ, and the imaging depth is also limited. [0003] X-ray fluorescence imaging plays an important role in the fields of medical...

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But X-rays don't have the ability to mark and trace

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