Near infrared fluorescence-X-ray dual mode small animal imaging equipment

An imaging device, X-ray technology, applied in the field of biomedical imaging, can solve the problem that X-rays do not have the ability to mark and trace, and achieve the effect of accurate imaging results

Pending Publication Date: 2017-07-21
苏州影睿光学科技有限公司
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Problems solved by technology

But X-rays don't have the ability to mark and trace

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  • Near infrared fluorescence-X-ray dual mode small animal imaging equipment

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Embodiment Construction

[0025] In order to make the objectives, technical solutions, and advantages of the present invention clearer, the following further describes the present invention in detail with reference to specific embodiments and drawings.

[0026] Such as figure 1 As shown, the present invention belongs to a near-infrared fluorescence-X-ray dual-mode small animal imaging device. The fluorescence imaging device includes an excitation light source 1, an X-ray source 2, a fluorescence detector 3, a focusing objective 4, a stage, and 5 , X-ray fluorescence conversion screen 6, filter 7 and computer 8.

[0027] The excitation light source 1 is used to excite the object to be imaged on the stage 4, and the excitation light source within the wavelength range of 700-1350nm can be freely selected according to the needs of different excitation wavelengths; it can also be different fluorescence intensity according to the actual object to be imaged The power of the excitation light source is adjusted to ...

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Abstract

The invention discloses a near infrared fluorescence-X-ray dual mode small animal imaging equipment. The imaging equipment is composed of an excitation source, an X-ray source, an X-ray fluorescence conversion screen, a light filter, a focusing objective lens, a fluorescence detector, an object stage and a computer, wherein the wavelength of the fluorescence detector ranges from 400 nanometer to 1700 nanometer, the excitation source, the fluorescence detector, the light filter combination and the transparent object stage can be controlled through the computer, and the computer can also shoot and output images and save them. According to the near infrared fluorescence-X-ray dual mode small animal imaging equipment, objects to be imaged can be subjected to near infrared fluorescence imaging and X-ray imaging to obtain the fluorescence images, and the advantages of the two imaging modes complement each other.

Description

Technical field [0001] The invention relates to the technical field of biomedical imaging, in particular to a near-infrared fluorescence-X-ray dual-mode small animal imaging equipment. Background technique [0002] Near-infrared two-zone fluorescence (NIR-II 1000-1700 nm) greatly reduces the absorption and scattering of photons by biological tissues, and there is almost no biological autofluorescence interference. Therefore, compared with the traditional visible and near-infrared one-zone fluorescence (400- 900 nm) in vivo imaging, near-infrared two-zone fluorescence imaging has better tissue penetration depth and higher spatial resolution. The near-infrared fluorescence imaging system can perform real-time imaging and tracing in vivo, and can observe the whole process of labeled cells in the body, but it cannot distinguish the specific position of the organ, and the imaging depth is also limited. [0003] X-ray fluorescence imaging plays an important role in the fields of medical...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B6/00
CPCA61B5/0035A61B5/0064A61B5/0071A61B6/44A61B6/482A61B6/508A61B6/5247A61B2503/40
Inventor 孙国凤刘莉丽
Owner 苏州影睿光学科技有限公司
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