Medicine for treating heart failure and preparation method and application thereof

The technology of a drug and lentils, applied in the field of medicine, can solve the problems of obvious side effects, limited clinical application, etc., and achieve the effects of significant curative effect, comprehensive drug action, and improving medication compliance.

Inactive Publication Date: 2017-08-11
佳木斯大学附属第一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although western medicine has achieved certain effects, its clinical application is greatly limited due to obvious side effects
At present, most of the existing traditional Chinese medicine prescriptions for the treatment of heart failure contain aconitine, and its active ingredient "aconitine" can excite the adrenergic β-receptors of the heart and blood vessels, and may also stimulate the α-receptors, and may also release catecholamines.

Method used

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  • Medicine for treating heart failure and preparation method and application thereof

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Effect test

Embodiment 1

[0028] In the embodiment of the present invention, a drug for treating heart failure is composed of the following raw materials: 15 kg of lentils, 11 kg of chicken feather grass, 3 kg of dew hives, and 23 kg of wild chrysanthemums.

[0029] Grind the lentils, pass through a 100-mesh sieve, soak them in an acetic acid solution with a volume concentration of 60% at a temperature of 45°C for 1.8 hours, and then conduct microwave treatment for 3 minutes with a microwave power of 600W to obtain a lentil solution. Grind the gallinaceae and wild chrysanthemum, pass through a 80-mesh sieve, add deionized water 12 times the mass of the two, and conduct ultrasonic treatment for 35 minutes. The ultrasonic temperature is 65°C, and the ultrasonic power is 1000W. liquid. Crush the dew honeycomb, pass through a 100-mesh sieve, add deionized water 10 times its mass, heat to 60°C and stir at this temperature for 1.2h at a stirring speed of 300r / min, then heat up to 68°C and Stir for 0.8h, cen...

Embodiment 2

[0031] In the embodiment of the present invention, a drug for treating heart failure is composed of the following raw materials: 25 kg of lentils, 19 kg of chicken feather grass, 7 kg of dew hives, and 31 kg of wild chrysanthemums.

[0032] Grind the lentils, pass through a 100-mesh sieve, soak them in an acetic acid solution with a volume concentration of 60% at a temperature of 48°C for 2 hours, and then conduct microwave treatment for 5 minutes with a microwave power of 600W to obtain a lentil solution. Grind the gallinaceae and wild chrysanthemum, pass through a 80-100 mesh sieve, add deionized water 13 times the mass of the two, and perform ultrasonic treatment for 40 minutes. The ultrasonic temperature is 68 ° C, and the ultrasonic power is 1000 W. Get a mixture. Crush the dew honeycomb, pass through a 120-mesh sieve, add deionized water 10.5 times its mass, heat to 62°C and stir at this temperature for 1.4h at a stirring speed of 350r / min, then heat up to 70°C and Stir...

Embodiment 3

[0034] In the embodiment of the present invention, a drug for treating heart failure is composed of the following raw materials: 18 kg of lentils, 13 kg of chicken feathers, 4 kg of dew hives, and 25 kg of wild chrysanthemums.

[0035] Grind the lentils, pass through a 100-mesh sieve, soak them in an acetic acid solution with a volume concentration of 60% at a temperature of 46°C for 1.9 hours, and then conduct microwave treatment for 4 minutes with a microwave power of 600W to obtain a lentils solution. Grind the gallinaceae and wild chrysanthemum, pass through a 100-mesh sieve, add deionized water 12.5 times the mass of the two, and perform ultrasonic treatment for 38 minutes. The ultrasonic temperature is 66 ° C, and the ultrasonic power is 1000 W. liquid. Crush the dew honeycomb, pass through a 120-mesh sieve, add deionized water 10.2 times its mass, heat to 61°C and stir at this temperature for 1.3h at a stirring speed of 320r / min, then heat up to 69°C and Stir for 0.9 h...

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Abstract

The invention discloses a medicine for treating heart failure and a preparation method and an application thereof. The medicine is composed of the following raw materials in parts by weight: 15-25 parts of Phyllanthusreticulatus Poir, 11-19 parts of denseleaf crazyweed herb, 3-7 parts of nidus vespae and 23-31 parts of mother chrysanthemum. The preparation method comprises the following steps of: crushing and sieving the Phyllanthusreticulatus Poir, and performing soaking and microwave treatment in an acetate solution to obtain a Phyllanthusreticulatus Poir solution; crushing and sieving the denseleaf crazyweed herba nd mother chrysanthemum, and adding deionized water for ultrasonic treatment and centrifugalization to prepare a mixed liquid; crushing and sieving the nidus vespae, and adding deionized water to heat, stir, centrifugalize, and removing the precipitate to obtain a nidus vespae solution; and mixing the Phyllanthusreticulatus Poir solution, the mixed liquid and the nidus vespae solution, and stirring the mixture to perform ultrasonic treatment and stirring the mixture to be dry to obtain the medicine. The medicine disclosed by the invention has the advantages of being high in curative effect, free of toxic and side effects, low in price and the like when used for treating heart failure, in particular chronic cardiac failure. The raw materials of the medicine disclosed by the invention are easily available, and the medicine is simple in preparation method and exact in curative effect and has a wide clinical application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for treating heart failure and its preparation method and application. Background technique [0002] Heart failure is the terminal stage of various cardiovascular diseases. If various internal and external factors lead to long-term overload of the heart before and after the load, myocardial disease damage and weakened contractility, heart failure can all lead to the occurrence of heart failure. With the development of medicine, the treatment of heart failure is also in progress. Among them, chronic heart failure refers to a clinical syndrome in which various reasons lead to cardiac structural and / or functional abnormalities that impair the ability of ventricles to eject blood or fill. The morbidity and mortality of chronic heart failure show a rising trend, and its late mortality is equivalent to that of cancer. The resulting medical expenses and social burdens are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P9/04A61K35/64
Inventor 陈颖岳彩芳孙佳斌徐建博房丽
Owner 佳木斯大学附属第一医院
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