Method for extracting cholic acid from cholic acid leftovers

A technology of leftovers and cholic acid, used in steroids, organic chemistry, etc.

Active Publication Date: 2019-04-26
湖南迪博制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no comprehensive utilization method for the recovery of cholic acid from the leftovers after extracting cholic acid from the pharmacopoeia source cattle and sheep bile

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take cattle or sheep bile, add 100g / L sodium hydroxide, heat and boil for 12-18 hours to obtain saponified liquid. After cooling, add acid to adjust the pH value to 1, and cholic acid is precipitated. The cholic acid is taken out, boiled, rinsed, dried at 75°C, and ground into powder to obtain crude bovine and sheep cholic acid. The filtrate was concentrated to obtain asphalt-like scraps.

Embodiment 2

[0028] The scrap 100kg of embodiment 1, add solid NaOH saponification 18 hours by 1: 1, add 2 times of 20% BaCl again 2 Boil for 20 minutes, then let stand for 10-24 hours, filter, wash the solid with water, and collect it for use. Supernatant with H 2 SO 4 Acidify, adjust pH to 3-4, filter to get crude cholic acid, add NaOH at 1:0.4, saponify for 4 hours, add 2 times 15% BaCl 2 , cooled, filtered. Add Na to the filtrate at 1:0.4 2 CO 3 , boil and filter. Filtrate with H 2 SO 4 Adjust the pH to 3-4, boil, filter to obtain agglomerated cholic acid, dry, add (95% ethanol and 5% activated carbon) at 1:6 for decolorization (8) recover 3 / 4 ethanol, and crystallize to obtain about 50 kg of finished cholic acid , the purity is between 60-70%.

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PUM

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Abstract

The invention discloses a method for extracting cholic acid from cattle and sheep cholic acid leftovers, and the method comprises the following steps: (1) adding NaOH into the cholic acid leftovers for saponification; (2) adding a BaCl2 solution into saponification liquid, and heating to remove grease; (3) standing the solution, and filtering to obtain supernatant; (4) acidifying the supernatant with H2SO4, adjusting pH to 3-4, and filtering to obtain crude cholic acid. The preferred method also allows secondary saponification and degreasing of the crude cholic acid. The method also relates to a method for obtaining barium salts with industrial use from the cattle and sheep cholic acid leftovers.

Description

technical field [0001] The invention relates to the comprehensive utilization of artificial taurocholic acid extraction waste. Background technique [0002] Bezoar is the dried gallstones of cattle, and is a precious and rare medicinal material. It has unique effects in treating convulsions, convulsions and convulsions. my country's natural bezoar has always been obtained by slaughtering by farmers, and the natural occurrence rate is less than 1%. However, the annual consumption of the domestic pharmaceutical industry needs at least 5,000 kilograms, and resources are seriously scarce. In order to solve the problem of its resource shortage, my country successfully developed artificial bezoar in the 1960s, that is, referring to the known components of natural bezoar, extracted from the bile of cattle, pigs, sheep and other animals, and composed of bovine bile powder, taurine, and cholic acid. , hyodecholic acid, bilirubin, etc., has similar pharmacological effects to natural b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00
CPCC07J9/005
Inventor 宋卫星高尚
Owner 湖南迪博制药有限公司
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