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Application of long-chain non-coding lncRNA-OD1 in osteoporosis

A long-chain non-coding, osteoporosis technology, applied in the field of molecular biomedicine, to achieve the effect of high development value

Active Publication Date: 2017-10-20
AFFILIATED HOSPITAL OF JIANGNAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far there is no study on the expression of LncRNA in the process of osteoporosis.

Method used

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  • Application of long-chain non-coding lncRNA-OD1 in osteoporosis
  • Application of long-chain non-coding lncRNA-OD1 in osteoporosis
  • Application of long-chain non-coding lncRNA-OD1 in osteoporosis

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Experimental program
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Embodiment Construction

[0030]Below in conjunction with accompanying drawing and operation method, the present invention is described in detail.

[0031] 1. Method

[0032] 1.1 Osteoporosis group: randomly selected 10 patients with primary osteoporosis admitted to the orthopedics department of the hospital, 5 males and 5 females, aged 65-75 years. The inclusion criteria met: the second draft of "Recommended Diagnostic Criteria for Osteoporosis in China". No other obvious heart, liver, lung and other diseases, no various diseases that cause secondary osteoporosis, and those who have bone metabolism caused by thyroid, tumor, diabetes and other serious diseases are excluded. Normal group: 10 healthy outpatient volunteers aged 65-75 were selected, 5 males and 5 females. There was no statistically significant difference in age and sex between the two groups (p>0.01), which were comparable. All research subjects gave informed consent.

[0033] 1.2 Blood RNA extraction: TRI pure LS Reagent is used for R...

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Abstract

The applicant provides a long-chain non-coding lncRNA-OD1 which is formed by transcribing a gene located at a chromosome 18: chr18: 77343316-77345492, hg19, and the length of the gene sequence is 2177bp. The applicant also provides application of the long-chain non-coding lncRNA-OD1 in preparation of a reagent, a kit or a gene chip for predicting osteoporosis. In the invention, through a gene chip technology, a bioinformatics technology and a molecular biological technology, whether abnormal expression occurs in an LncRNA in an osteoporosis process can be determined, and the function of the LncRNA in the pathogenetic process of osteoporosis is understood, so that a new clue is provided for early diagnosis of osteoporosis, and a molecular mechanism of occurrence of osteoporosis is enriched favorably.

Description

technical field [0001] The invention relates to the technical field of molecular biomedicine, in particular to the application of a long-chain non-coding RNA in the assessment and prevention of osteoporosis risk. Background technique [0002] With the increasing aging of the global population, osteoporosis has become one of the diseases that seriously threaten social public health. The incidence rate of osteoporosis among the elderly in my country reaches 15.7%. [1] , the most serious consequence is osteoporotic fracture, which poses a serious threat to the patient's physical and mental health, a great drag on the family, and a heavy economic burden on the society. [2] . Therefore, the early detection and prevention of osteoporosis is particularly important. [0003] The current laboratory tests for osteoporosis include: (1) blood calcium, phosphorus and alkaline phosphatase: in primary osteoporosis, serum calcium, phosphorus and alkaline phosphatase levels are usually no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113C12Q1/68
CPCC12N15/113C12Q1/6883C12Q2600/158C12Q2600/178
Inventor 袁凤来李霞姜东林徐瑞生王雪松叶俊星
Owner AFFILIATED HOSPITAL OF JIANGNAN UNIV
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