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Microwave-assisted extraction method of three lactone compounds in rhizoma chuanxiong

A microwave-assisted, compound technology, applied in solid solvent extraction, chemical/physical/physical-chemical processes using energy, etc., can solve the problems of high cost, unfavorable dispersion and mass transfer, and high viscosity, and achieve small temperature fluctuations and selectivity. Strong, high extraction efficiency

Active Publication Date: 2017-11-03
DONGGUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows for quicker heating up while also reducing any changes that may affect its effectiveness or harm it's ability to produce certain chemical substances from Lactones. It achieves this through an efficient process involving different types of solvents like water-based solutions (water), dimethyl sulfoxide) or ethanolic solution containing various salts such as lithium hydrogen carbonate).

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the efficiency and effectiveness of various types of ionics without causing harmful side effects during production and usage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Take by weighing choline chloride and ethylene glycol (molar ratio 1:2) the deep eutectic solvent 30g that forms, and particle size is 60 order Rhizoma Chuanxiong powder 1g, under 800rpm magnetic stirring condition, reaction tube is put into microwave reactor, Connect the pressure-sensing tube and the temperature-sensing optical fiber, set the temperature to 160°C, and set the extraction time to 5 minutes. After the extraction is finished, after the sample is cooled to room temperature, dilute the sample with methanol, filter, then transfer it to a volumetric flask, and dilute to volume with methanol. Utilize high-performance liquid chromatography, adopt internal standard method, measure three kinds of lactone compounds: ligustilide, chuanxionglide I and chuanxionglide H concentration are respectively: 193.2mg / L, 15.5mg / L, 3.8mg / L L.

Embodiment 2

[0039]Take by weighing choline chloride and ethylene glycol (molar ratio 1:2) the deep eutectic solvent 20g that forms, and particle size is 80 mesh Rhizoma Chuanxiong powder 1g, under 600rpm magnetic stirring condition, put reaction tube into microwave reactor, Connect the pressure-sensing tube and the temperature-sensing optical fiber, set the temperature to 160°C, and set the extraction time to 1 min. After the extraction is finished, after the sample is cooled to room temperature, dilute the sample with a small amount of methanol, filter, then transfer it to a volumetric flask, and dilute to volume with methanol. Utilize high-performance liquid chromatography, adopt internal standard method, measure three kinds of lactone compounds: ligustilide, ligustilide I and ligustilide H concentrations are respectively: 123.5mg / L, 10.8mg / L, 2.6mg / L L.

Embodiment 3

[0041] Take by weighing choline chloride and ethylene glycol (molar ratio 1:2) the deep eutectic solvent 10g that forms, particle size is 160 mesh Rhizoma Chuanxiong powder 1g, under 1000rpm magnetic stirring condition, reaction tube is put into microwave reactor, Connect the pressure-sensing tube and the temperature-sensing optical fiber, set the temperature to 160°C, and set the extraction time to 1 min. After the extraction is finished, after the sample is cooled to room temperature, dilute the sample with a small amount of methanol, filter, then transfer it to a volumetric flask, and dilute to volume with methanol. Utilize high performance liquid chromatography, adopt internal standard method, measure three kinds of lactone compounds: ligustilide, ligustilide I and ligustilide H concentrations are respectively: 106.2mg / L, 8.7mg / L, 2.1mg / L L.

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Abstract

The invention relates to a microwave-assisted extraction method of three lactone compounds in rhizoma chuanxiong and belongs to the field of extraction separation. The microwave-assisted extraction method includes: allowing an extracting agent to contact with rhizoma chuanxiong powder, wherein the extracting agent is a deep eutectic solvent formed by choline chloride and acetic acid, propionic acid or ethylene glycol according to the mole ratio of 1:1-1:5. The microwave-assisted extraction method has the advantages that ligustilide, senkyunolide I and senkyunolide H in the rhizoma chuanxiong powder can be extracted, the extraction efficiency of the lactone compounds can reach 180mg/L, and the method is high in extraction efficiency, high in selectivity, mild in operation condition and environmentally friendly.

Description

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Claims

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Application Information

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Owner DONGGUAN UNIV OF TECH
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