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Ambroxol hydrochloride oral solution and preparation method thereof

A kind of oral ambroxol hydrochloride, ambroxol hydrochloride technology, applied in the field of ambroxol hydrochloride oral solution and preparation thereof, can solve the problems such as poor taste of ambroxol hydrochloride oral solution, achieve the reduction of medication risk, prevent aggregation, taste suitable effect

Inactive Publication Date: 2017-11-21
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the technical problem that the mouthfeel of ambroxol hydrochloride oral solution is poor, the inventor first thinks of selecting a kind of ambroxol hydrochloride oral solution and preparation method thereof

Method used

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  • Ambroxol hydrochloride oral solution and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: take by weighing ambroxol hydrochloride, polyethylene glycol, hydroxypropyl cellulose, L-cystine, sucrose, sodium benzoate and distilled water, be 1:6:5:2:2:3 by weight :50, mix, filter, sterilize, fill, promptly get the ambroxol hydrochloride oral solution.

Embodiment 2

[0012] Embodiment 2: Take by weighing ambroxol hydrochloride, polyethylene glycol, hydroxypropyl cellulose, L-cystine, sucrose, sodium benzoate and distilled water, be 1:6:5:2:4:5 by weight :50, mix, filter, sterilize, fill, promptly get the ambroxol hydrochloride oral solution.

Embodiment 3

[0013] Embodiment 3: take by weighing ambroxol hydrochloride, polyethylene glycol, hydroxypropyl cellulose, L-cystine, sucrose, sodium benzoate and distilled water, be 1:6:5:2:3:4 by weight :50, mix, filter, sterilize, fill, promptly get the ambroxol hydrochloride oral solution.

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Abstract

The invention discloses an ambroxol hydrochloride oral solution. The ambroxol hydrochloride oral solution consists of ambroxol hydrochloride, polyethylene glycol, hydroxy propyl cellulose, L-cystine, saccharose, sodium benzoate and distilled water. The ambroxol hydrochloride oral solution is suitable in taste, effectively covers intense bitter taste of active ingredients, and is convenient to take orally and high in stability.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical liquid oral preparations, and in particular relates to an ambroxol hydrochloride oral solution and a preparation method thereof. Background technique [0002] Ambroxol hydrochloride is a mucolytic agent, which can increase the secretion of serous glands of the respiratory mucosa, reduce the secretion of mucus glands, reduce the viscosity of sputum, promote the secretion of pulmonary surfactant, increase the movement of bronchial cilia, and make sputum easy to cough up. At present, there are four kinds of ambroxol hydrochloride dosage forms: oral solution, tablet, capsule, and sustained-release capsule. Because the oral solution dosage form is unstable, it is generally necessary to add preservatives to prolong the shelf life, which brings hidden dangers to drug safety; and the existing product taste Poor, greatly affecting the patient's willingness to use. Contents of the invention [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/137A61K47/10A61K47/18A61K47/38A61P11/10
CPCA61K9/0095A61K31/137A61K47/10A61K47/183A61K47/38
Inventor 李洋
Owner NANJING ZHENGKUAN MEDICAL TECH
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