A kind of ultra-high drug-loaded nanoparticles and preparation method thereof

A drug-loaded nanometer and nanoparticle technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effect of increasing particle size distribution and reducing workload

Active Publication Date: 2022-04-01
刘东飞 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The combination of two or more stabilizers can produce a synergistic effect, but some specific stabilizers will cause the aggregation of drug nanocrystal particles due to the interaction [6]

Method used

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  • A kind of ultra-high drug-loaded nanoparticles and preparation method thereof
  • A kind of ultra-high drug-loaded nanoparticles and preparation method thereof
  • A kind of ultra-high drug-loaded nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Such as figure 1 As shown, this embodiment discloses a preparation device for ultra-high drug-loaded nanoparticles, including a first reactor 1 and a second reactor 2; the first reactor includes a first inlet 1a, a second inlet 1b and a first outlet 1c, the second reactor comprises a third inlet 2a and a fourth inlet 2b.

[0091] Optional situation 1: the first inlet 1a is used to add the first reactant, and the first reactant enters the first reactor 1 through the first inlet 1a; the second inlet 1b is used to add the second reactant, and the second inlet 1b is used to add the second reactant. Two reactants along figure 1 The direction of the arrow next to the second inlet 1b enters the first reactor 1; the first reactor 1 is used to accommodate the reaction of the first reactant and the second reactant. Optional situation 2: the first inlet 1a is used to add the second reactant, and the second reactant enters the first reactor 1 through the first inlet 1a; the secon...

Embodiment 2

[0095] Such as figure 2 As shown, the difference between this embodiment and embodiment 1 is that the pre-accommodating chamber 3 is not used, the first inlet and the first reactor are arranged on the same straight line, and the first reactor and the second reactor are arranged on the same straight line . There are two second inlets, which are respectively perpendicular to the straight line formed by the first inlet and the first reactor. There are two third inlets, which are respectively perpendicular to the straight line formed by the first reactor and the second reactor. The first reactant and the second reactant enter the first reactor through the first inlet and the second inlet respectively, or the first reactant and the second reactant enter the first reactor through the second inlet and the first inlet respectively. Interchanging the piping of the first reactant and the second reactant into the first reactor does not affect the production of nanoparticles. This exa...

Embodiment 3

[0097] Such as image 3 As shown, the difference between this embodiment and embodiment 2 is that there is one second inlet, and the first inlet and the second inlet are respectively obliquely connected to the first reactor, forming an incident angle with the first reactor ( 0 to 180 degrees), and the rest are the same. The first reactant and the second reactant enter the first reactor through the first inlet and the second inlet respectively, or the first reactant and the second reactant enter the first reactor through the second inlet and the first inlet respectively. Interchanging the piping of the first reactant and the second reactant into the first reactor does not affect the production of nanoparticles. This example is directed to a reactor prepared by using polymer materials such as PDMS. The dashed part in the middle indicates that the length of the reactor can be adjusted.

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Abstract

The invention discloses an ultra-high drug-loaded nanoparticle, which includes a nano-core containing an active pharmaceutical ingredient and a drug release-controlled shell; wherein, the mass of the active pharmaceutical ingredient accounts for 30-85% of the mass of the entire nanoparticle; said The particle size of ultra-high drug-loaded nanoparticles is 50-2000nm. The invention also discloses the preparation method of the above-mentioned ultra-high drug-loaded nanoparticles and the special equipment in the above-mentioned preparation method.

Description

technical field [0001] The invention relates to an ultrahigh drug-loaded nanoparticle and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] The development of nanotechnology has greatly accelerated research in medical science. The application of nanotechnology to the prevention, diagnosis and treatment of diseases is called nanomedicine. The global market for nanomedicine will increase from US$5.5 billion in 2011 to US$12.7 billion in 2016. Nano drug delivery systems, such as nanoparticle carriers, are mainly composed of lipid materials and / or polymers, as well as their entrapped therapeutic drugs [1] , can improve the curative effect of traditional medicine. Although some nano-drug delivery systems have been successfully applied to the diagnosis and treatment of clinical diseases, such as cancer, pain and infection, there are still many aspects to be improved in the development of nano-drug delive...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/38A61K47/12A61K47/26A61K47/32A61K31/337A61K31/44A61K31/635A61K31/4745A61K31/355A61K38/28A61K31/573A61K31/12A61K31/65A61K31/40
CPCA61K9/5123A61K9/5138A61K9/5161A61K31/12A61K31/337A61K31/355A61K31/40A61K31/44A61K31/4745A61K31/573A61K31/635A61K31/65A61K38/28A61K47/12A61K47/26A61K47/32A61K47/38A61K9/51
Inventor 刘东飞海尔德A.桑托斯凡进殷国勇
Owner 刘东飞
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