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Application of resveratrol

A technology of resveratrol and endometrial cancer, applied in the direction of active ingredients of hydroxyl compounds, drug combinations, anti-tumor drugs, etc., can solve the physiological and mental health threats of EC patients with recurrence risk of reproductive function, and achieve low toxic and side effects , less toxic and side effects, good anti-tumor activity

Inactive Publication Date: 2017-11-24
XUZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Although surgery combined with radiotherapy and chemotherapy can achieve a good therapeutic effect, the loss of postoperative reproductive function and the risk of recurrence caused by conservative treatment still pose a serious threat to the physical and mental health of EC patients.

Method used

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  • Application of resveratrol
  • Application of resveratrol
  • Application of resveratrol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Regulatory effect of resveratrol on the occurrence and development of endometrial cancer.

[0032] 1. Experimental materials:

[0033] 1.1 Experimental animals: ICR mice, female, SPF grade, provided by Shanghai Xipuer-Bikai Experimental Animal Co., Ltd., license number: SCXK (Shanghai) 2013-0016.

[0034] 1.2 Experimental drug: purified diet containing resveratrol (800 mg / kg), the drug was purchased from Beijing Bailingwei Technology Co., Ltd.

[0035] 1.3 Reagents and configuration:

[0036] Monofunctional alkylating agent methyl nitrosoguanidine (N-methyl-N'-nitro-N-nitrosoguanidine.MNNG) and resveratrol were purchased from Beijing Bailingwei Technology Co., Ltd.; NaCl, Na 2 HPO 4 12H 2 O. KH 2 PO 4 , KCl, polyethylene glycol, chloroform, isopropanol, and absolute ethanol were purchased from Sinopharm Chemical Reagent Co., Ltd.; TRIzol was purchased from Invitrogen Corporation of the United States; hematoxylin and eosin (HE) staining kit was purchased...

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Abstract

The invention discloses application of resveratrol in the preparation of a drug for treating endometrial cancer. Experiments prove that when the dosage of the resveratrol is 800mg / kg, the resveratrol is capable of obviously inhibiting the development of the cancer of a mouse with the endometrial cancer, has no obvious influence to the body weight of the mouse and has no obvious toxicity to organs of the mouse, so that the resveratrol is low in toxic and side effects and can be applied to the preparation of the drug for treating the endometrial cancer; and the application field of the resveratrol is exploited, and the resveratrol has good anti-tumor activity, low toxic and side effects and obvious social benefits.

Description

technical field [0001] The invention relates to an application of resveratrol. Background technique [0002] Endometrial cancer (EC) is one of the most common gynecological tumors, the fourth most common cancer in gynecological cancers in developed countries such as Europe and North America, and the sixth most common cancer in the world. In recent years, the incidence of EC in my country has also increased year by year, and the age of onset is getting younger and younger. The proportion of women younger than 40 years old in EC patients has reached 15%, and 70% of them have not given birth. Although surgery combined with radiotherapy and chemotherapy can achieve a good therapeutic effect, the loss of postoperative reproductive function and the risk of recurrence caused by conservative treatment still pose a serious threat to the physical and mental health of EC patients. Compared with other cancers, the biggest feature of EC is that its occurrence and development are closely...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P35/00
CPCA61K31/05
Inventor 印晓星周雪妍尹家乐王席尹弟杜蕾
Owner XUZHOU MEDICAL UNIV
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