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Compound medicinal composition having function of treating Alzheimer's disease and application of compound medicinal composition

A composition and senile technology, applied in the direction of drug combination, organic active ingredients, active ingredients of hydrocarbon compounds, etc., can solve the problems of lack of dose-effect relationship/time-effect relationship and achieve good synergistic effects

Active Publication Date: 2017-12-08
佛山市第五人民医院 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to historical reasons, the existing research on the pharmaceutical composition of natural active ingredients of traditional Chinese medicine is mainly scientific discovery of pharmacological activity exploration research, lack of scientific and systematic research on dose-effect relationship / time-effect relationship, pharmacokinetics research and dose-toxicity relationship research. necessary basis for research

Method used

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  • Compound medicinal composition having function of treating Alzheimer's disease and application of compound medicinal composition
  • Compound medicinal composition having function of treating Alzheimer's disease and application of compound medicinal composition
  • Compound medicinal composition having function of treating Alzheimer's disease and application of compound medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: compound pharmaceutical composition 1

[0020] Mix perylene amide and lycopene at a weight ratio of 1:10. For uniform mixing, about 2 to 3 times the weight of water was added to the combined extracts, which were then concentrated under vacuum at 50-60°C. Then, add an equal amount of water to the obtained concentrate again to suspend it evenly, and freeze-dry the obtained suspension to prepare compound pharmaceutical composition 1 in powder form.

Embodiment 2

[0021] Embodiment 2: Compound pharmaceutical composition 2

[0022] Mix perylene amide and lycopene at a weight ratio of 1:50. For uniform mixing, about 2 to 3 times the weight of water was added to the combined extracts, which were then concentrated under vacuum at 50-60°C. Then, add an equal amount of water to the obtained concentrate again to suspend it evenly, and freeze-dry the obtained suspension to prepare compound pharmaceutical composition 2 in powder form.

Embodiment 3

[0023] Embodiment 3: Compound pharmaceutical composition 3

[0024] Mix perylene amide and lycopene at a weight ratio of 1:100. For uniform mixing, about 2 to 3 times the weight of water was added to the combined extracts, which were then concentrated under vacuum at 50-60°C. Then, add an equal amount of water to the obtained concentrate again to suspend it evenly, and freeze-dry the obtained suspension to prepare compound pharmaceutical composition 3 in powder form.

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Abstract

The invention belongs to the field of natural medicines, and discloses a compound medicinal composition having a function of treating Alzheimer's disease and an application of the compound medicinal composition. An active ingredient of the compound medicinal composition consists of piperlongumine and lycopene at the mass ratio of 1: (10-500). The compound medicinal composition, on the basis of a synergistic effect between the piperlongumine and the lycopene under certain dosages, is capable of treating the Alzheimer's disease.

Description

technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to a compound medicinal composition capable of treating senile dementia and its application. Background technique [0002] The pharmacological activity, activity relationship (additive or synergistic), pharmacological activity intensity, dose-effect relationship / time-effect relationship, absorption and bioavailability, dose-toxicity relationship, etc. of each component in the pharmaceutical composition. Pharmaceutical compositions generally have a variety of pharmacological Activity, usually with outstanding advantages and the strongest pharmacological activity is preferred as the direction of indication development. Pharmacological activity and pharmacological activity intensity are the cornerstones of drug dosage formulation; determination of combination ratio is the core and key of drug research and development. The compatibility ratio is very closely related to the c...

Claims

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Application Information

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IPC IPC(8): A61K31/4412A61K31/01A61P25/28
CPCA61K31/01A61K31/4412A61K2300/00
Inventor 黄文柱王志军刘连刘腾彭咏波严文
Owner 佛山市第五人民医院
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