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New application of geraniol

A technology of geraniol and its uses, which is applied in the field of geraniol and its derivatives, and can solve problems such as mastitis in dairy cows where geraniol has not been found

Inactive Publication Date: 2018-01-19
CHENGDU MEDICAL COLLEGE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is no report on the use of geraniol in the prevention and treatment of mastitis in dairy cows

Method used

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  • New application of geraniol
  • New application of geraniol
  • New application of geraniol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 The present invention treats dairy cow mastitis medicine

[0019] The medicine can be prepared by extracting from plants, or can be purchased directly. Geraniol is purchased from Sigma-aldrich, batch number MKBQ1662V, and a preparation prepared by adding pharmaceutically acceptable adjuvants or auxiliary ingredients.

experiment example 1

[0020] Experimental Example 1: Curative Effect of the Invented Drug on Anti-clinical Mastitis in Dairy Cows

[0021] 1 Experimental materials

[0022] 1.1 Drugs

[0023] Invention drug: Geraniol was purchased from Sigma-aldrich, batch number MKBQ 1662V.

[0024] 1.2 Experimental animals

[0025] Holstein lactating cows imported from Uruguay suffering from clinical mastitis in a dairy farm in Sichuan Province.

[0026] 1.3 Media and reagents

[0027] 0.9% Sodium Chloride Injection, batch number B16051903, was purchased from Sichuan Kelun Pharmaceutical Co., Ltd.; McFarney Turbidimetric Tube was purchased from bioMerieux SA.

[0028] 1.4 Main Instruments

[0029] Biological safety cabinet (BIOsafe12), Shanghai Lishen Scientific Instrument Co., Ltd.; automatic autoclave (HICLAVEHVE-50), Japan HIRAYAMA Company; water-proof constant temperature incubator, Shanghai Yiheng Scientific Instrument Co., Ltd.; electric blast drying oven (GZX-9240MBE), Medical Equipment Factory of Sh...

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PUM

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Abstract

The invention provides application of geraniol to preparation of medicines for treating cow mastitis as well as a medicinal composition containing the geraniol. The geraniol is applied to cow mastitisand has accurate medicinal effect; the geraniol belongs to a pure natural preparation, is not treated by an organic solvent and is safe and reliable; the geraniol has low toxicity and does not have adverse reaction after long-time use; and the geraniol can repair the infected mammary tissues and is suitable for acute, subacute and chronic cow clinical mastitis.

Description

technical field [0001] The present invention relates to the new application of geraniol and its derivatives. Background technique [0002] The symptoms of cow mastitis are inflammation of the udder parenchyma and interstitium. The etiology is mostly caused by mechanical stimulation, infiltration of pathogenic microorganisms and chemical and physical damage. Clinical mastitis is inflammation of breast stroma, parenchyma or interstitial parenchyma, which is characterized by milk degeneration, swelling of breast tissue in varying degrees, warmth and pain, and can be divided into acute , subacute and chronic mastitis. [0003] The etiology of dairy cow udder inflammation is very complex, including environmental management factors, pathogen infection, cow's own factors and secondary factors and so on. TCM treatment needs to be treated according to syndrome differentiation. [0004] Geraniol (trans-3,7-dimethyl-2,6-octadien-1-ol), also known as "geraniol" is a monoterpene alco...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P15/14A61P29/00
Inventor 代敏彭成曹小玉
Owner CHENGDU MEDICAL COLLEGE