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Patch preparation for treating liver cirrhosis and method for preparing patch preparation

A preparation and powder technology, which is applied in the field of patch preparation and preparation for the treatment of liver cirrhosis, and can solve problems such as organ damage

Inactive Publication Date: 2018-02-02
陕西中医肝肾病医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the existing drugs for the treatment of liver cirrhosis, which often take orally lowering the portal pressure, often accompanied by many side effects. Some patients are relatively weak due to the influence of liver cirrhosis. In order to solve the problem of organ damage, a patch preparation and preparation method for treating liver cirrhosis are provided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Make the patch preparation for the treatment of liver cirrhosis based on the following parts by weight ratio:

[0035] First, 3 parts of Glauber's salt, 6 parts of raw rhubarb, 6 parts of raw ephedra, and 6 parts of morning glory are dried at 60°C, crushed and ground into fine powder, and sieved with a 100-mesh sieve to obtain a combined powder;

[0036] Then add water to decoct 6 parts of large thistle, 3 parts of kansui, 6 parts of Tinglizi, and 6 parts of betel nut for 3 times. The volume of water added to each decoction is 12 times the volume of the raw material, and decocted for 2 hours each time. After filtering, Concentrate and dry under the environment of -0.08MPa and 60°C to obtain the No. 2 combination powder;

[0037] Then mix No. 1 combination powder, No. 2 combination powder and matrix according to the ratio, and stir until solidified to form a paste.

[0038] Finally, divide the paste into three parts, and the weight ratio of the three parts is 1:2:3. The l...

Embodiment 2

[0042] Make the patch preparation for the treatment of liver cirrhosis based on the following parts by weight ratio:

[0043] First, 10 parts of Glauber's salt, 10 parts of raw rhubarb, 10 parts of raw ephedra, and 10 parts of morning glory are dried at 60°C, crushed and ground into fine powder, and sieved with a 100-mesh sieve to obtain a combined powder;

[0044] Then add water to decoct 10 parts of large thistle, 10 parts of kansui, 10 parts of Tinglizi, and 10 parts of betel nut for 3 times. The volume of water added to each decoction is 12 times the volume of the raw material, and decocted for 2 hours each time. After filtering, Concentrate and dry under the environment of -0.09MPa and 60°C to obtain the No. 2 combination powder;

[0045] Then mix No. 1 combination powder, No. 2 combination powder and matrix according to the ratio, and stir until solidified to form a paste.

[0046] Finally, divide the paste into three parts, and the weight ratio of the three parts is 1:...

Embodiment 3

[0050] Make the patch preparation for the treatment of liver cirrhosis based on the following parts by weight ratio:

[0051] First, 6 parts of mirabilite, 8 parts of raw rhubarb, 8 parts of raw ephedra, and 8 parts of morning glory are dried at 60°C, crushed and ground into fine powder, and sieved with a 100-mesh sieve to obtain a combined powder;

[0052] Then add water to decoct 8 parts of large thistle, 7 parts of kansui, 8 parts of Tinglizi, and 8 parts of betel nut for 3 times. The volume of water added to each decoction is 12 times the volume of the raw material, and decocted for 2 hours each time. After filtering, Concentrate and dry under the environment of -0.09MPa and 60°C to obtain the No. 2 combination powder;

[0053] Then mix No. 1 combination powder, No. 2 combination powder and matrix according to the ratio, and stir until solidified to form a paste.

[0054] Finally, divide the paste into three parts, and the weight ratio of the three parts is 1:2:3. The lig...

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Abstract

The invention relates to the field of traditional Chinese medicine preparations, and discloses a patch preparation for treating liver cirrhosis and a method for preparing the patch preparation. The technical scheme includes that the patch preparation comprises medicine powder and matrixes; the medicine powder comprises natrii sulfas, radix et rhizoma rhei, herba cirsii japonici, euphorbia kansui,herba ephedrae, semen lepidii, semen arecae and semen pharbitidis, and the matrixes comprise Vaseline, lanolin and pine tar; the method includes drying, smashing and grinding the natrii sulfas, the radix et rhizoma rhei, the herba ephedrae and the semen pharbitidis to obtain fine powder, sieving the powder to obtain first combined powder, adding the herba cirsii japonici, the euphorbia kansui, thesemen lepidii and the semen arecae into water, decocting the herba cirsii japonici, the euphorbia kansui, the semen lepidii and the semen arecae, and carrying out filtering, concentrating and dryingto obtain second combined powder, proportionally mixing the first combined powder, the second combined powder and the matrixes with one another to obtain mixtures and stirring the mixtures until the mixtures are solidified to obtain paste so as to obtain the patch preparation. The patch preparation and the method have the advantage that the problems of frequent side effects of oral portal pressurereducing medicines mostly used for treating liver cirrhosis at present, aggravation of weak constitution of partial patients after the patients take treatment medicaments due to the weak constitutionunder the influence of the liver cirrhosis and possible injury to other organs can be solved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a plaster preparation for treating liver cirrhosis and a preparation method thereof. Background technique [0002] Liver cirrhosis is a common clinical chronic progressive liver disease, which is diffuse liver damage caused by long-term or repeated effects of one or more causes. In my country, most of them are post-hepatitis cirrhosis, and a small part are alcoholic cirrhosis and schistosome cirrhosis. Histopathologically, extensive liver cell necrosis, nodular regeneration of residual liver cells, connective tissue hyperplasia, and fibrous septum formation lead to structural destruction of hepatic lobules and formation of pseudolobules. The liver gradually deforms and hardens and develops into cirrhosis. In the early stage, there are no obvious symptoms due to the strong compensatory function of the liver. In the later stage, liver function damage and po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K9/70A61P1/16A61K33/04
CPCA61K9/7076A61K33/04A61K36/17A61K36/185A61K36/28A61K36/31A61K36/39A61K36/47A61K36/708A61K36/744A61K36/889A61K2300/00
Inventor 丁殿利
Owner 陕西中医肝肾病医院
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