Pyrimidine derivatives, preparation method therefor and application of pyrimidine derivatives

Abstract

The invention belongs to the field of drug synthesis and relates to novel pyrimidine derivatives, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, preparation methods of thenovel pyrimidine derivatives and the pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof and use of the novel pyrimidine derivatives and the pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof in preparation of therapeutic agents, particularly PAK inhibitors. The derivatives disclosed by the invention are represented by a general formula (I) or (II), wherein each substituent is as defined in claims.

Description

technical field [0001] The invention belongs to the field of drug synthesis, and relates to a class of novel pyrimidine derivatives, pharmaceutically acceptable salts, hydrates, solvates or prodrugs of the derivatives, their preparation methods and their use in the preparation of therapeutic agents, especially Use in the preparation of PAK inhibitors. Background technique [0002] Protein kinase is currently the largest known protein superfamily. Since the discovery of protein kinase activity in 1954, research in this field has developed rapidly. There are about 538 protein kinases that have been discovered, and their coding genes account for about About 2% of the human genome. As follows: [0003] [0004] Protein kinase catalyzes the transfer of the terminal phosphate group of ATP to a specific amino acid of the substrate in vivo to phosphorylate the substrate. According to the type of amino acid residues phosphorylated in the substrate protein, they can be divided in...

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