Oil-in-water type fructus hippophae oil nanoemulsion external preparation and method for preparing same

An external preparation, oil-in-water type technology, applied in the fields of biomedicine and skin care, can solve the problems of poor water solubility and stability, limiting clinical application, etc., achieve thermodynamic stability, improve therapeutic effect, and good uniformity

Inactive Publication Date: 2018-02-09
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there are few external preparations of sea buckthorn oil for skin, and because sea buckthorn oil is an essential oil substance, its water solubility and stability are poor, which limits its clinical application. In order to improve the stability of sea buckthorn oil and broaden the application range of sea buckthorn oil, pharmaceutical research The authors conducted a variety of formulation studies
However, seabuckthorn oil has no officially approved skin external preparation for the treatment of ACD (variant contact dermatitis)

Method used

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  • Oil-in-water type fructus hippophae oil nanoemulsion external preparation and method for preparing same
  • Oil-in-water type fructus hippophae oil nanoemulsion external preparation and method for preparing same
  • Oil-in-water type fructus hippophae oil nanoemulsion external preparation and method for preparing same

Examples

Experimental program
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Effect test

Embodiment 1

[0025] At 25°C, accurately weigh 0.2g of polyoxyethylene castor oil, 0.05g of diethylene glycol monoethyl ether and 0.0625g of isopropyl myristate, place them in a stoppered ampoule, and stir with a constant temperature magnetic stirrer , stir magnetically at a speed of 200rpm min-1 for 5min to fully mix; accurately weigh 0.25g of seabuckthorn oil and place it in the above ampoule, stir magnetically at a speed of 200rpm min-1 for 2min to fully stir the mixture evenly; then Slowly add 3g of distilled water dropwise to the mixture, and stir while adding water. During the process of adding water and stirring, the mixture system will change from thin to viscous, and finally from viscous to clear, until an oil-in-water nanoemulsion is formed. .

[0026] figure 1 The middle black area is the O / W microemulsion 4; the black solid line area is the liquid crystal 3; the area surrounded by the black dotted line at the top is the W / O microemulsion area 1; the area surrounded by the black...

Embodiment 2

[0030] 0.2 g of polyoxyethylene castor oil, 0.05 g of diethylene glycol monoethyl ether, 0.17 g of isopropyl myristate, 0 g of seabuckthorn oil, and 3.0 g of distilled water.

Embodiment 3

[0032] 0.125 g of polyoxyethylene castor oil, 0.125 g of diethylene glycol monoethyl ether, 0.0125 g of isopropyl myristate, 0.05 g of seabuckthorn oil, and 3.0 g of distilled water.

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Abstract

The invention relates to a natural medicine extract nanoemulsion external preparation, belongs to the field of biomedical and skin healthcare technologies, and provides an oil-in-water type fructus hippophae oil nanoemulsion external preparation. The oil-in-water type fructus hippophae oil nanoemulsion external preparation comprises, by weight, 0.4%-5.0% of isopropyl myristate, 3.8%-6.0% of polyoxyethylenated castor oil, 1.4%-3.8% of diethylene glycol monoethyl ether, 0%-7.0% of fructus hippophae oil and the balance distilled water. The sum of the mass percents of components is 100%. The oil-in-water type fructus hippophae oil nanoemulsion external preparation has the advantages that prepared fructus hippophae oil nanoemulsion which is external fructus hippophae oil nanoemulsion is stablein quality and difficult to volatile, the stability of the fructus hippophae oil can be improved, accordingly, the storage time of the fructus hippophae oil can be prolonged, and the in-vivo medicinemetabolism time of the fructus hippophae oil can be delayed; raw materials and energy can be saved by a method for preparing the oil-in-water type fructus hippophae oil nanoemulsion external preparation, accordingly, the production cost can be reduced, the method is nearly free of environmental pollution, processes for preparing the oil-in-water type fructus hippophae oil nanoemulsion external preparation are simple and are easy to actually implement, special instruments or equipment can be omitted, the oil-in-water type fructus hippophae oil nanoemulsion external preparation can be efficiently and quickly prepared, industrialization can be facilitated, and the oil-in-water type fructus hippophae oil nanoemulsion external preparation and the method have broad market prospects in the fieldof medicines.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and skin care, and in particular relates to an oil-in-water seabuckthorn oil nanoemulsion external preparation and a preparation method thereof. Background technique [0002] Seabuckthorn (Hippophaerhamnoides Linn) is a plant of the genus Hippophae (Cassia Occidentalis L.), which is extracted and isolated from Hippophae hamnoides. It is a traditional Mongolian medicine and Tibetan medicine. Seabuckthorn oil is rich in a large number of nutritional active substances, which has gradually attracted the attention of the medical community in recent years, and systematic research has been carried out on its resources, pharmacology, preparations, and clinics, and it has been confirmed that seabuckthorn oil is a drug with strong pharmacological activity, high efficiency and safety . [0003] Modern studies have shown that seabuckthorn oil has the functions of preventing and treating gastric ulcer, pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/107A61K47/44A61K47/14A61K47/10A61P17/02A61P29/00
CPCA61K9/0014A61K9/1075A61K36/185A61K47/10A61K47/14A61K47/44
Inventor 王梅
Owner XINJIANG MEDICAL UNIV
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