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Activity of compound salvia miltiorrhiza pills for treating osteoporosis and application of compound salvia miltiorrhiza pills

A technology of osteoporosis and Fangdanshen, applied in medical preparations containing active ingredients, pill delivery, bone diseases, etc.

Active Publication Date: 2018-02-09
杨中林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research report on the activity of Jingfang Danshen Pills in the treatment of osteoporosis

Method used

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  • Activity of compound salvia miltiorrhiza pills for treating osteoporosis and application of compound salvia miltiorrhiza pills
  • Activity of compound salvia miltiorrhiza pills for treating osteoporosis and application of compound salvia miltiorrhiza pills
  • Activity of compound salvia miltiorrhiza pills for treating osteoporosis and application of compound salvia miltiorrhiza pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Comparative study on the activity of different compositions of Jingfang Danshen Pills and its prescription drugs on promoting the proliferation rate of MC3T3-E1 osteoblasts

[0016] 1. Purpose of the experiment

[0017] A comparative study of the activity of 60 different compositions of Jingfang Danshen Pills and its prescription drugs in promoting the proliferation rate of MC3T3-E1 osteoblasts was carried out. The cell proliferation rate was used as an index, and the MTT experiment method was used. One concentration for each composition, each Each plate has 1 well, and a total of 6 plates are used to screen out the composition with the best curative effect of Jingfang Danshen Pills.

[0018] 2. Experimental equipment

[0019] 2.1 Experimental Instruments

[0020] BS-124S ​​type 1 / 10000 electronic balance (sartorius, Beijing Sartorius Instrument System Co., Ltd.), TB-25 type 1 / 100,000 electronic balance (DENVER, Beijing Denver Instrument Co., Ltd.), HH-4 typ...

Embodiment 2

[0044] Example 2 In Vivo Pharmacodynamics Study of Treating Ovariectomized Model Rats with Ovariectomized Danshen Pills

[0045] In this experiment, the ovariectomized rat model of osteoporosis was selected, and the levels of hydroxyproline (HOP) in serum, alkaline phosphatase (ALP) in serum, osteocalcin (OCN) in serum and anti- The content of tartrate acid phosphatase 5b (TRACP-5b), the content of estradiol (E2) in serum, the content of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) in serum; HOP content, urinary calcium content, urinary phosphorus content; femoral bone density; bone calcium and bone phosphorus content and other indicators, to verify the in vivo pharmacological activity of Fangdanshen pills in the treatment of osteoporosis in ovariectomized rats.

[0046] 1. Experimental materials

[0047] 1.1 Main Instruments

[0048] TDL80-2B desktop centrifuge (Shanghai Anting Scientific Instrument Factory); CSS-4420 electronic univ...

Embodiment 3

[0154] Embodiment 3 through the preparation of Fang Danshen pill granules

[0155] Weigh the Jingfang Danshen pill extract powder prepared in Example 1, add dextrin or starch as an auxiliary material 1 to 5 times the mass of the extract powder, mix evenly, pass through a 65-mesh sieve, and use an appropriate amount of 95% ethanol as a binder. Made into wet materials, extruded and granulated through a 20-mesh sieve, and dried at 65°C to obtain granules.

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Abstract

The invention discloses the activity of compound salvia miltiorrhiza pills for treating osteoporosis and the application of the compound salvia miltiorrhiza pills. By a comparative research on the activity of the compound salvia miltiorrhiza pills for promoting the MC3T3-E1 osteoblast proliferation rate, a result shows that the compound salvia miltiorrhiza pills has an outstanding effect of promoting bone growth. Compared with different compositions of formula medicines, the compound salvia miltiorrhiza pills have a pharmaceutical effect advantage. A result of an in-vivo pharmacodynamics research on the compound salvia miltiorrhiza pills for treating the osteoporosis of an ovariectomized rat model shows that the compound salvia miltiorrhiza pills has an outstanding effect of treating the rat model suffering from the osteoporosis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of Jingfang Danshen Pills in the preparation of medicines for treating osteoporosis. Background technique [0002] Jingfang Danshen Wan Jingfang comes from Volume 19 of "Prescriptions for Emergencies". It is composed of Danshen, Eucommia, Achyranthes bidentata, Dipsacus, Guixin and dried ginger. It is mainly used to treat waist and leg pain. Jingfang Danshen Pill is mainly used to treat waist and leg pain, which belongs to the category of bone numbness in traditional Chinese medicine. However, there is no research report on the activity of Jingfang Danshen Pills in treating osteoporosis. Contents of the invention [0003] The object of the present invention is to provide the application of Jingfang Danshen Pill in the preparation of medicine for treating osteoporosis. [0004] The purpose of the present invention can be achiev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/20A61P19/10
CPCA61K9/2068A61K36/185A61K36/21A61K36/46A61K36/537A61K36/54A61K36/9068A61K2300/00
Inventor 杨中林
Owner 杨中林
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