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A solution preparation for nebulization and inhalation of Andrographis paniculata paniculata and its preparation method

A technology of atomization inhalation and Andrographis paniculata, applied in the field of formulations, can solve the problems of no standardized use method in the manual, hidden dangers of use, etc., and achieve the effects of easy treatment effect and comparative treatment effect.

Active Publication Date: 2021-07-30
INCREASEPHARM HENGQIN INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical practice, nebulized inhalation with injection is often used, but there is no standardized method of use in the instructions, and there are potential safety hazards in use

Method used

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  • A solution preparation for nebulization and inhalation of Andrographis paniculata paniculata and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Preparation of Andrographis paniculata ethanol extract:

[0035] Andrographis paniculata leaves, add 20 times the amount of 90% ethanol for hot soaking and extracting 3 times, 4 hours each time, combine the extracts, filter, recover the ethanol from the filtrate to 1:1.5, add 5-6% activated carbon, heat and reflux for 30 minutes, and heat it while it is hot Filtrate, wash the filter residue with an appropriate amount of ethanol, combine the filtrate, add 3 times the amount of ethanol fed, stir evenly, let stand for 24 hours, filter, recover ethanol from the filtrate, and make a liquid extract.

[0036] (2) Preparation of Andrographis paniculata aerosol inhalation solution:

[0037] Andrographis paniculata ethanol extract 4g

[0038] Sodium chloride 9g

[0039] β-cyclodextrin amount

[0040] Add water for injection to 1000ml

[0041] Weigh the ethanol extract of Andrographis paniculata according to the prescription, add 30ml of aqueous solution containing an appr...

Embodiment 2

[0044] (1) Preparation of ethanol extract of Andrographis paniculata: same as Example 1.

[0045] (2) Preparation of Andrographis paniculata aerosol inhalation solution:

[0046] Andrographis paniculata ethanol extract 7g

[0047] Sodium chloride 6g

[0048] Hydroxypropyl-β-cyclodextrin appropriate amount

[0049] Add water for injection to 1000ml

[0050] Weigh the ethanol extract of Andrographis paniculata according to the prescription, add 40ml of aqueous solution containing an appropriate amount of hydroxypropyl-β-cyclodextrin, grind it to a paste, add half an amount of water for injection, stir to dissolve, add activated carbon, stir well, and boil for 30min , allowed to cool to room temperature, refrigerated for 24 hours, filtered, added water for injection to 980ml, added 6g of sodium chloride, dissolved, added water for injection to 1000ml, adjusted pH to 7.0, ultrafiltered, potted, sterilized, and obtained the present invention Solution formulations.

[0051] The...

Embodiment 3

[0053] (1) Preparation of ethanol extract of Andrographis paniculata: same as Example 1.

[0054] (2) Preparation of Andrographis paniculata aerosol inhalation solution:

[0055] Andrographis paniculata ethanol extract 3g

[0056] Glucose 100g

[0057] Hydroxypropyl-β-cyclodextrin appropriate amount

[0058] Add water for injection to 1000ml

[0059] Weigh the ethanol extract of Andrographis paniculata according to the prescription amount, add 10ml of an aqueous solution containing an appropriate amount of hydroxypropyl-β-cyclodextrin, grind it to a paste, add half an amount of water for injection, stir to dissolve, add activated carbon, fully stir, and boil for 30 minutes , let cool to room temperature, refrigerate for 24 hours, filter, add water for injection to 980ml, add 100g glucose, dissolve, add water for injection to 1000ml, adjust pH to 3.0, ultrafilter, potting, and sterilize to obtain the solution preparation of the present invention .

[0060] The obtained nebul...

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Abstract

The invention relates to a solution preparation for nebulization and inhalation of Andrographis paniculata, belonging to the field of pharmacy. A solution preparation of Andrographis paniculata for nebulization and inhalation, comprising (1) an active ingredient of Andrographis paniculata; (2) an isotonic agent and a solvent. The solution preparation prepared by the present invention makes up the gap in the current domestic market, and the solution preparation prepared by the present invention is specially designed for patients with nebulized inhalation. After nebulized by the compressed nebulizer, it is directly inhaled into the respiratory system in the form of nebulization. Play a role in the treatment of upper respiratory tract infection, sore throat, lung heat cough and so on.

Description

technical field [0001] The invention relates to a solution preparation for atomized inhalation of Andrographis paniculata and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Andrographis paniculata, also known as Yijianxi, Wanbing Xiancao, Sizhibang, etc., is bitter in taste and cold in nature, and has the effects of clearing heat and detoxifying, cooling blood and stopping bleeding. The main component of Andrographis paniculata is Andrographis lactis, which has the effect of clearing away heat and detoxifying, and is used for the treatment of upper respiratory tract infection, sore throat, cough due to lung heat, etc. Due to its good therapeutic effect, Andrographis paniculata has been developed into common dosage forms such as tablets, capsules, injections, soft capsules, and dripping pills, and has been widely used. [0003] The traditional oral dosage form has a large dosage and cannot directly act on the patient site. It ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/72A61K36/19A61P11/04A61P11/14A61P11/00
CPCA61K9/0078A61K36/19A61K47/40
Inventor 张保献李艳英
Owner INCREASEPHARM HENGQIN INST CO LTD
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