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Kechuanning solution preparation for atomized inhalation and preparation method thereof

A technology of atomized inhalation and Kechuanning, which is applied in the field of pharmaceuticals, can solve the problems of no suitable dosage form, no use of atomized inhalation preparations, and fewer products, so as to increase compliance, improve safety, and reduce dosage Effect

Inactive Publication Date: 2018-03-09
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few products on the market for nebulized inhalation solution preparations, mainly imported products
Kechuanning is an oral dosage form, and there is no clinical application of nebulized inhalation preparations.
At the same time, traditional Chinese medicine has a good curative effect on upper respiratory tract infection, but there is no suitable dosage form to make it more effective.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of active ingredients of Kechuanning:

[0031] 26.8g ephedra, 13.4g gypsum, 26.6g bitter almond, 13.4g platycodon, 13.4g centipede, 13.4g poppy shell, 26.6g licorice

[0032] The above seven flavors and gypsum are crushed into fine powder, decocted with water for 1 hour, filtered, and the filtrate is used for later use; the dregs and other six flavors such as ephedra are decocted twice, and the pH value is adjusted to 5.0 with hydrochloric acid after adding water each time, 1.5 h each time. Filtrate, combine the filtrates, add the above standby medicinal liquid, concentrate to a clear paste, let it cool, add ethanol to make the alcohol content reach 70%, refrigerate and stand for 48 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add 3 times the amount Add water, adjust the pH to 5.0, heat to boil, refrigerate, stand for 48 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcoho...

Embodiment 2

[0040] (1) Preparation of active ingredients of Kechuanning:

[0041] 67g ephedra, 33.5g gypsum, 66.5g bitter almond, 33.5g platycodon, 33.5g centipede, 33.5g poppy shell, 66.5g licorice

[0042] The above seven flavors and gypsum are crushed into fine powder, decocted with water for 1 hour, filtered, and the filtrate is used for later use; the dregs and other six flavors such as ephedra are decocted twice, and the pH value is adjusted to 5.0 with hydrochloric acid after adding water each time, 1.5 h each time. Filtrate, combine the filtrates, add the above standby medicinal liquid, concentrate to a clear paste, let it cool, add ethanol to make the alcohol content reach 75%, refrigerate and stand for 48 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add 4 times the amount Add water, adjust the pH to 5.0, heat to boil, refrigerate, stand for 48 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol ...

Embodiment 3

[0050] (1) Preparation of active ingredients of Kechuanning:

[0051] Ephedra 53.6g, Gypsum 26.8g, Bitter Almond 53.2g, Campanulaceae 26.8g, Baibu 26.8g, Poppy Shell 26.8g, Licorice 53.2g

[0052] The above seven flavors and gypsum are crushed into fine powder, decocted with water for 1 hour, filtered, and the filtrate is used for later use; the dregs and other six flavors such as ephedra are decocted twice, and the pH value is adjusted to 5.0 with hydrochloric acid after adding water each time, 1.5 h each time. Filtrate, combine the filtrates, add the above standby medicinal liquid, concentrate to a clear paste, let it cool, add ethanol to make the alcohol content reach 75%, refrigerate and stand for 48 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add 2 times the amount Add water, adjust the pH to 7.0, heat to boil, refrigerate, stand for 48 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol...

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Abstract

The invention relates to a Kechuanning solution preparation for atomized inhalation, and belongs to the field of galenic pharmacy. The Kechuanning solution preparation for atomized inhalation comprises (1) Kechuanning active ingredients; (2) an isotonic agent and a solvent. The solution preparation prepared by the invention makes up for the gaps in the current domestic market, and the solution preparation prepared by the invention is specifically designed for a patient for atomized inhalation, and the prepared solution preparation for atomized inhalation is atomized by an ultrasonic atomizer or air compression atomizer, and then is directly inhaled into a respiratory system in the form of atomization, and the use process is convenient. Compared with a Kechuanning oral solution, the administration routes are different, the dose is reduced, the effect is fast, the safety is improved, and the effects of treating chronic cough and asthma due to excessive phlegm can be realized.

Description

technical field [0001] The invention relates to a solution preparation for nebulized inhalation of Kechuanning and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Kechuanning is a classic Chinese patent medicine. Its main ingredients are ephedra, gypsum, bitter almond, platycodon grandiflorum, basil, poppy shell, licorice, etc. It has the effect of dredging lung qi, relieving cough and relieving asthma. For chronic cough, phlegm wheezing with phlegm-heat syndrome, symptoms include frequent cough, yellow phlegm, shortness of breath and chest tightness. Existing Kechuanning preparations include tablets, capsules, oral liquids and the like. Because of its clear curative effect and long history of medication, it is a typical representative of traditional Chinese medicine for Xuanfei Qingre. [0003] The traditional oral dosage form has a large dosage and cannot directly act on the patient site. It needs to enter the circulatory s...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/72A61K9/08A61K47/02A61K47/26A61P11/06A61P11/10A61P11/14A61K33/06
CPCA61K9/0078A61K9/08A61K33/06A61K36/17A61K36/346A61K36/484A61K36/66A61K36/736A61K36/904A61K47/02A61K47/10A61K47/26A61P11/00A61P11/06A61P11/10A61P11/14A61K2300/00
Inventor 张保献李艳英
Owner BEIJING INCREASEPHARM CORP LTD
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