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Establishment method of mouse influence model on ulcerative colitis by selenized oligomeric aminopolysaccharide (LSA)

A technology for ulcerative colitis and method establishment, which is applied in the field of establishing a model of selenized oligoaminopolysaccharides on ulcerative colitis mice, can solve problems such as the inability to cure IBD diseases, and achieve obvious and significant intestinal oxidative damage Antioxidant effect, effect of reducing MDA and iNOS content

Active Publication Date: 2018-06-29
ZHEJIANG OCEAN UNIV
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Problems solved by technology

Although the level of medical treatment has improved in recent years, it is still impossible to completely cure the disease of IBD

Method used

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  • Establishment method of mouse influence model on ulcerative colitis by selenized oligomeric aminopolysaccharide (LSA)
  • Establishment method of mouse influence model on ulcerative colitis by selenized oligomeric aminopolysaccharide (LSA)
  • Establishment method of mouse influence model on ulcerative colitis by selenized oligomeric aminopolysaccharide (LSA)

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Embodiment Construction

[0044] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0045] A method for establishing a model of selenized oligoaminopolysaccharides affecting ulcerative colitis mice,

[0046] (a) Take 40 male BALB / C mice aged 6-8 weeks, with a body weight of 18-22 g, and after three days of adaptive feeding, divide them into four groups of ten in each group:

[0047] Normal group: feed with distilled water, and gavage with aqueous solution, once a day for 10 days, and the amount of infusion is 200 μl / day;

[0048] LSA group: fed with distilled water, and gavaged with selenized oligoaminopolysaccharide (LSA) aqueous solution, once a day for 10 days, and the amount of infusion was 200 μl / day;

[0049] LSA+DSS group: fed with distilled water for the first three days, fed with 3.5% dextran sodium sulfate (DSS) aqueous solution for the next seven days, and fed with 500 mg / kg selenized oligoaminopolysaccharide (LSA)...

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Abstract

The invention discloses an establishment method of a mouse influence model on an ulcerative colitis by selenized oligomeric aminopolysaccharide. Influences on the ulcerative colitis, induced by the fact that DSS (Dextran Sulfate Sodium) is mediated by the selenized oligomeric aminopolysaccharide (LSA), are detected through a living mouse model. A research result shows that compared with a DSS model group, the content of mouse blood DAO (Diamine Oxidase), lysozyme and D-LAC of an LSA group is reduced, and the content of tight junction protein and mucoprotein is increased; HE dyeing and scanningelectron microscope display structures are obvious and are more complete and the permeability of a mouse intestinal mucosa is reduced; the LSA can be used for remarkably alleviating inflammatory factor abnormal expression caused by the DSS through inhibiting a phosphorylation level of an NF-kappaB p65 related signal pathway, and inhibiting the raising of a colitis related oxidization index MDA and oxidase iNOS concentration.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a method for establishing a model of the effect of selenized oligoaminopolysaccharide on ulcerative colitis mice. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic non-specific enteritis that has a relatively high incidence in my country in recent years. The pathogenesis of IBD is still unclear, but the current consensus is that external environmental factors affect congenital genetic susceptibility. Effects in infected patients. IBD includes ulcerative colitis (ulcerative colitis, UC) and Crohn's disease (Crohndisease, CD). UC can occur in people of any age group. In recent years, the incidence of UC in my country has been gradually increasing, and there is a trend of younger patients. Patients with UC are mainly high-risk groups such as colon and rectal cancer. In the process of cancer cell generation, inflammatory factors play a greater role, such as the ...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P1/04
CPCA61K31/722
Inventor 闻正顺王晓波
Owner ZHEJIANG OCEAN UNIV
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