Graphostroma sp. 3A00421 and applications of fermentation compounds of Graphostroma sp. 3A00421

A technology for compounds and polyketone compounds, which can be used in the active ingredients of hydroxyl compounds, fermentation, fungi, etc., can solve problems such as adverse reactions, and achieve the effect of promoting effective application and good application prospects.

Active Publication Date: 2018-07-10
THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since the existing chemically synthesized anti-inflammatory drugs still have unavoidable adverse reactions, researchers are paying more and more attention to finding and developing new anti-inflammatory drugs from natural products.

Method used

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  • Graphostroma sp. 3A00421 and applications of fermentation compounds of Graphostroma sp. 3A00421
  • Graphostroma sp. 3A00421 and applications of fermentation compounds of Graphostroma sp. 3A00421
  • Graphostroma sp. 3A00421 and applications of fermentation compounds of Graphostroma sp. 3A00421

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Experimental program
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Embodiment 1

[0036] In this embodiment, the deep-sea fungus Graphostroma sp.3A00421 is used as a material to prepare the fermentation compound of the deep-sea fungus Graphostroma sp.3A00421 shown in formula (I) to formula (XXV). The specific steps are as follows:

[0037] (1) The strains were cultured in PDA plate medium at 25°C for 3 days, then the fresh mycelium was cut and inoculated in 1L Erlenmeyer flasks (30 pieces), and each Erlenmeyer flask was equipped with 80g rice and 120mL distilled water , these Erlenmeyer flasks were placed under the condition of 25°C, cultured statically for 28 days, and the fermentation product was extracted after the fermentation;

[0038] (2) The fermentation product obtained in step (1) is extracted 3 times with ethyl acetate respectively to obtain an organic extract;

[0039] (3) Concentrate the organic extract obtained in step (2) to dryness and redissolve it with methanol, then extract it 3 times through petroleum ether (PE), and finally evaporate the...

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Abstract

The invention discloses Graphostroma sp. 3A00421 and applications of fermentation compounds of the Graphostroma sp. 3A00421, wherein the Graphostroma sp. 3A00421 is preserved in China Center for TypeCulture Collection on October 30, 2017, and has the preservation number of CCTCC NO: M 2017637, and the preservation address is Wuhan University in Wuhan city in China. According to the present invention, the fermentation compounds of the Graphostroma sp. 3A00421 have anti-allergic activity and anti-inflammatory activity, and can be used for preparing anti-allergic or anti-inflammatory drugs; andthe new compound source is provided for the research and development of anti-allergic and anti-inflammatory drugs, the important significance is provided for the development of marine drugs in China,the effective applications of deep-sea microbial resources can be promoted, and good application prospect is provided.

Description

technical field [0001] The invention belongs to the application field of marine fungus extract compounds, more specifically, the invention relates to the application of deep-sea fungus Graphostroma sp.3A00421 and its fermentation compounds. Background technique [0002] Food allergy refers to the strong reaction of a certain tissue, organ or even the whole body after some people eat a certain food, resulting in various dysfunction or tissue damage. The incidence of food allergy has gradually increased in the past few decades, posing a threat to human life and health. Food allergic reactions are mainly mediated by serum immunoglobulin E (IgE), and this allergic reaction is usually accompanied by an increase in the content of specific immunoglobulin IgE. [0003] At present, there is no active drug that inhibits allergenic food antigens, and the current treatment options for food allergy are avoidance of contact with allergens or desensitization therapy. The use of dietary i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14C12P17/14C12P17/06C12P17/04C12P7/42C12P7/26C12P7/02A61K31/421A61K31/12A61K31/343A61K31/192A61K31/366A61K31/235A61K31/122A61K31/047A61K31/19A61P29/00A61P37/08C12R1/645
CPCA61K31/047A61K31/12A61K31/122A61K31/19A61K31/192A61K31/235A61K31/343A61K31/366A61K31/421C12P7/02C12P7/26C12P7/42C12P17/04C12P17/06C12P17/14C12N1/145C12R2001/645
Inventor 杨献文牛四文夏金梅谢春兰骆祝华李增鹏
Owner THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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