Composition containing butyric acid and its application

A compound and composition technology, applied in the direction of drug combination, application, anhydride/acid/halide active ingredients, etc., can solve the problems of no safe and effective prevention and treatment measures, and achieve the promotion of cholestatic liver fibrosis, effective liver fibrosis The effects of curing and preventing biliary atresia

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A compound and composition technology, applied in the direction of drug combination, application, anhydride/acid/halide active ingredients, etc., can solve the problems of no safe and effective prevention and treatment measures, and achieve the promotion of cholestatic liver fibrosis, effective liver fibrosis The effects of curing and preventing biliary atresia

CN108283632BInactive Publication Date: 2019-06-07XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1

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Embodiment 1

[0042] This embodiment provides an infant formula milk powder containing coated butyric acid and a preparation method thereof. The method is as follows: adding food-grade coated butyric acid to the infant formula milk powder and mix uniformly to obtain it. The concentration of the coated butyric acid in the prepared milk formula is 5 mmol / L.

Embodiment 2

[0044] This embodiment provides a maternal formula milk powder containing sodium butyrate and a preparation method thereof. The method is as follows: adding food-grade sodium butyrate to the maternal formula milk powder and mix uniformly to obtain it. The concentration of sodium butyrate in the prepared milk formula is 15 mmol / L.

Embodiment 3

[0046] This embodiment provides a preterm infant formula milk powder containing butyric acid glyceride and a preparation method thereof. The method is as follows: adding food grade butyric acid glyceride formula milk powder to the preterm infant formula milk powder and mixing uniformly to obtain the formula. The concentration of butyric acid glyceride in the prepared milk formula is 20 mmol / L.

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Abstract

The invention provides a composition comprising a butyric acid compound and an application of the composition. The butyric acid compound is used for preventing and curing biliary atresia and the complications. The composition comprising the butyric acid compound comprises the butyric acid compound and a nutrition agent or a pharmaceutical aid, and the concentration of the butyric acid compound is5-70 mM. The intervention technique generally acting on the intestine is creatively used to prevent and cure the biliary atresia and the complications. As a safe effective preventing and curing method, the butyric acid compound is directly used or added in the nutrition agent and used for pregnant and newborn individuals having no symptoms, so that the occurrence and development of the biliary atresia is prevented and cured fundamentally. The composition solves the technical problems of prevention and cure of complications of the biliary atresia and hepatic fibrosis at the same time, and a safe economical effective method is provided for the prevention and cure of biliary atresia and hepatic fibrosis.

Description

Technical field [0001] The present invention relates to the technical field of food and medicine, in particular to a composition containing butyric acid compounds and its application in preventing and treating biliary atresia and its complications. Background technique [0002] Biliary atresia (BA) is a congenital malformation characterized by progressive obstruction of the bile ducts inside and outside the liver, with an incidence of 1 / 5000-1 / 8000. Most children with BA usually have no obvious symptoms within a few days after birth. With progressive obstruction of the bile ducts inside and outside the liver, they gradually show obvious jaundice and clay-colored stools. Hilarjejunostomy is the preferred treatment for biliary atresia. However, even if the bile duct patency is successfully restored through the portojejunostomy, after normal bile drainage, progressive bile duct obstruction will still occur, leading to rapid development of liver fibrosis to cirrhosis. Without liver...

Claims

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Application Information

Patent Timeline

07 Jun 2019

Publication

CN108283632B

IPC: A61K31/19; A61K31/22; A61P1/16; A61P1/00; A23C9/16; A23C9/152; A23L33/10

CPC: A23C9/152; A23C9/16; A23L33/10; A23L33/40; A23V2002/00; A61K31/19; A61K31/22; A23V2200/30

Inventors: 文洁; 蔡威