Application of neryl acetate in preparing hypertensive myocardial fibrosis resisting medicine

A technology of neryl acetate and anti-hypertension, which is applied in the field of biomedicine, can solve problems such as the efficacy of neryl acetate that has not been mentioned, and achieve the purpose of increasing cardiac ejection fraction and short-axis shortening rate, reducing collagen content, and reducing body weight. The effect on systolic blood pressure

Inactive Publication Date: 2018-09-14
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no mention of neryl acetate's effect on high blood pressure or heart disease

Method used

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  • Application of neryl acetate in preparing hypertensive myocardial fibrosis resisting medicine
  • Application of neryl acetate in preparing hypertensive myocardial fibrosis resisting medicine
  • Application of neryl acetate in preparing hypertensive myocardial fibrosis resisting medicine

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Experimental program
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Embodiment Construction

[0024] The technical solution of the present invention will be further described below in combination with experiments.

[0025] In the following experiments, unless otherwise specified, the reagents, equipment and methods used in the present invention are those conventionally purchased in the art, equipment and conventional methods.

[0026] Preparation of drug solution

[0027] Preparation of Neryl acetate solution: Accurately weigh 250 mg, 500 mg, and 1000 mg of pure Neryl acetate (purchased from Beijing Puyihua Technology Co., Ltd., item number A19282), add 0.9% normal saline to dissolve and make to volume to 100mL to obtain 2.5mg / mL, 5mg / mL, and 10mg / mL solutions, and store them in a refrigerator at 4°C in the dark for later use.

[0028] Configuration of valsartan solution: ready-to-use, use a mortar to grind valsartan tablets into powder, accurately weigh 150mg, add 0.9% normal saline to dissolve and dilute to 100mL to obtain 1.5mg / mL of valsartan solution, protected...

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PUM

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Abstract

The invention discloses application of neryl acetate in preparing a hypertensive myocardial fibrosis resisting medicine. The invention discloses application of ester matter in preparing a hypertensionand / or heart disease resisting medicine and / or health products. A structural formula of the ester matter is shown in description, wherein the R1 is C1 to C3 alkyl, and the R2 and the R3 are hydrogenor C1 to C3 alkyl. The ester matter can reduce body systolic pressure and diastolic pressure to increase cardiac ejection fraction and shortening fraction, reduce a myocardium collagen content and enhance body heart functions, so that a novel selection direction is provided for treating hypertension, heart diseases and hypertensive myocardial fibrosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of neryl acetate in the preparation of antihypertensive myocardial fibrosis drugs. Background technique [0002] At present, there are 290 million patients with cardiovascular diseases in my country, including 270 million with hypertension, at least 7 million with stroke, 2.5 million with myocardial infarction, and 4.5 million with heart failure. On average, 1 in every 5 adults suffers from cardiovascular disease. Long-term high blood pressure can easily lead to functional damage and organic disease of heart, brain, kidney, blood vessels and other target organs. Myocardial fibrosis is common in many cardiovascular diseases and is the main pathological basis of hypertensive heart disease. It is also a potential risk factor for various cardiovascular events such as heart failure, arrhythmia and sudden cardiac death. Therefore, it is of great signifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/22A61P9/12A61P9/00
CPCA61K31/22A61P9/00A61P9/12
Inventor 张国华吕琳吴少瑜陈凯黄裕刘馨庄宇鑫管怡晴党文振马韵词
Owner SOUTHERN MEDICAL UNIVERSITY
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