Traditional Chinese medicine for treating restless leg syndrome and a preparation method thereof

A syndrome and uneasy technology, applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of large side effects of western medicine and achieve high safety effects

Active Publication Date: 2018-09-14
NANJING HOSPITAL OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention provides a traditional Chinese medicine for treating restless legs syndrome with remarkable curative effect and little side effects and a preparation method thereof, which solves the problems of large side effects of existing western medicines and the like

Method used

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  • Traditional Chinese medicine for treating restless leg syndrome and a preparation method thereof
  • Traditional Chinese medicine for treating restless leg syndrome and a preparation method thereof
  • Traditional Chinese medicine for treating restless leg syndrome and a preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Take 8 parts of Rehmannia, 8 parts of Angelica, 40 parts of Radix Paeoniae Alba, 12 parts of Rhizoma Chuanxiong, 4 parts of Lychee worms, 7 parts of Scorpion, 25 parts of Miltonia Spatholobus, and 12 parts of Radix Glycyrrhiza. The licorice is honey-roasted licorice, and the preparation method comprises the following steps:

[0030] a. Extract the volatile oil from Ligusticum chuanxiong and Angelica sinensis through steam distillation, add 10 times the weight of the medicinal materials when extracting, soak for 1 hour, and steam distill for 3 hours; add 4-8 times the weight of β-cyclodextrin to the volatile oil, Prepare β-cyclodextrin volatile oil clathrate by saturated aqueous solution method, when clathrate temperature is 30°C, stirring speed: 120r / min, clathrate for 0.5 hour, clathrate is vacuum-dried at 40°C for later use, distilled aqueous solution Another device collection;

[0031] b. Take the four flavors of Radix Paeoniae Alba, Scorpio, Spatholobus ...

Embodiment 2

[0034] Example 2: Take 12 parts of Rehmannia, 4 parts of Angelica, 60 parts of Radix Paeoniae Alba, 8 parts of Rhizoma Chuanxiong, 8 parts of Lychee worm, 3 parts of Scorpion, 35 parts of Miltonia Spatholobus, and 8 parts of Radix Glycyrrhizae, and the Radix Paeoniae Alba is fried Radix Paeoniae Alba The licorice is honey-roasted licorice, and the preparation method comprises the following steps:

[0035] a. Extract the volatile oil from Ligusticum chuanxiong and Angelica sinensis through steam distillation, add 10 times the weight of the medicinal materials when extracting, soak for 1 hour, and steam distill for 3 hours; add 4-8 times the weight of β-cyclodextrin to the volatile oil, Prepare β-cyclodextrin volatile oil clathrate by saturated aqueous solution method, when clathrate temperature is 30°C, stirring speed: 120r / min, clathrate for 0.5 hour, clathrate is vacuum-dried at 40°C for later use, distilled aqueous solution Another device collection;

[0036] b. Take the fo...

Embodiment 3

[0039] Example 3: Take 10 parts of Rehmannia, 6 parts of Angelica, 50 parts of Radix Paeoniae Alba, 10 parts of Rhizoma Chuanxiong, 6 parts of Lychee worm, 5 parts of Scorpio, 30 parts of Miltonia Spatholobus, and 10 parts of Radix Glycyrrhiza. The licorice is honey-roasted licorice, and the preparation method comprises the following steps:

[0040] a. Extract the volatile oil from Ligusticum chuanxiong and Angelica sinensis through steam distillation, add 10 times the weight of the medicinal materials when extracting, soak for 1 hour, and steam distill for 3 hours; add 4-8 times the weight of β-cyclodextrin to the volatile oil, Prepare β-cyclodextrin volatile oil clathrate by saturated aqueous solution method, when clathrate temperature is 30°C, stirring speed: 120r / min, clathrate for 0.5 hour, clathrate is vacuum-dried at 40°C for later use, distilled aqueous solution Another device collection;

[0041] b. Take the four flavors of Radix Paeoniae Alba, Scorpio, Spatholobus S...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine for treating the restless leg syndrome and a preparation method thereof. The traditional Chinese medicine is prepared from, by weight, 8-12 partsof dried radix rehmanniae, 4-8 parts of radix angelica sinensis, 40-60 parts of white peony root, 8-12 parts of ligusticum wallichii, 4-8 parts of Chinese polyphaga, 3-7 parts of scorpions, 25-35 parts of spatholobus suberctu and 8-12 parts of licorice root. The method includes the steps that radix angelica sinensis and ligusticum wallichii are extracted to volatile oil and are subjected to clathration with beta-cyclodextrin to obtain a clathrate compound; white peony root, scorpions, spatholobus suberctu and Chinese polyphaga are subjected to reflux through ethyl alcohol; dried radix rehmanniae, licorice root and medicine residues are decocted with water and prepared into a preparation. The traditional Chinese medicine has the effect of treating the restless leg syndrome, especially theyin deficiency and blood stasis type restless leg syndrome, no obvious toxic and side effects are found in the study, and the safety is high. The traditional Chinese medicine can be prepared into oralliquid in pharmacy and can be widely used.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating restless legs syndrome and its preparation method and application. Background technique [0002] Restless legs syndrome (RLS) is a common central sensorimotor disorder mainly involving the legs. When the patient sleeps or is quiet at night, he or she has indescribable discomfort in the lower legs, such as worms, tingling, swelling, numbness, etc., as well as a strong desire to move the legs, beating, moving the legs or getting out of bed and walking To relieve symptoms. RLS syndrome is often accompanied by insomnia, sleep fragmentation, daytime sleepiness, anxiety, and depression symptoms, which seriously affects life and is easily misdiagnosed and mistreated. Surveys in several countries in Europe and the United States show that the overall incidence of RLS syndrome is 5%-15%, and the incidence rate of women and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K47/69A61P25/00A61K35/646A61K35/64
CPCA61K35/646A61K36/232A61K36/236A61K36/484A61K36/486A61K36/65A61K36/71A61K36/804A61K2236/331A61K2236/39A61K2236/55A61K35/63A61K47/6951A61P25/00A61K2300/00
Inventor 冉颖卓
Owner NANJING HOSPITAL OF T C M
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