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Application of Vitamin C Derivatives in Preparation of Antitumor Products

A vitamin and derivative technology, applied in the field of medicine, can solve problems such as staying, and achieve the effect of inhibiting tumor cell proliferation and metastasis

Active Publication Date: 2019-12-03
BEIJING INST OF GENOMICS CHINESE ACAD OF SCI CHINA NAT CENT FOR BIOINFORMATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current research on vitamin C magnesium phosphate is still in the additive stage, which is mainly used in skin care products or feed additives, and uses its characteristics of eliminating oxygen free radicals to play wrinkle-removing and anti-aging effects; while for vitamin C Other uses of magnesium phosphate are rarely reported

Method used

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  • Application of Vitamin C Derivatives in Preparation of Antitumor Products
  • Application of Vitamin C Derivatives in Preparation of Antitumor Products
  • Application of Vitamin C Derivatives in Preparation of Antitumor Products

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Embodiment Construction

[0020] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0021] The present invention verifies the application effect of vitamin C derivatives in anti-tumor through the following tests:

[0022] Experiment 1. Vitamin C derivatives inhibit the proliferation of kidney cancer 786-O cells

[0023] S1: The vitamin C derivative vitamin C sodium and vitamin C phosphate magnesium were prepared into 100 μM respectively, and added to 786-O cells, and the medium containing vitamin C derivative was replaced with a new medium for each passage, and the treatment continued for 10 generations.

[0024] S2: Then the treated cells were planted in a 96-well plate at an appropriate density, and divided into 3 groups: a control group (untreated), a vitamin C sodium group, and a vitamin C magnesium phosphate group. During the culture period, the cell proliferation was continuously monitored for nearly 50 hours w...

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Abstract

The invention relates applications of vitamin C derivatives in antitumor products. According to the present invention, with the continuous and long-time administration of the low-dose vitamin C derivatives, the differentiation of cancer cells can be inhibited, and the malignant phenotype of cancer cells can be effectively inhibited, such that the evidence can be provided for the application of thevitamin C derivatives in tumor differentiation therapy.

Description

technical field [0001] The invention relates to the application of vitamin C derivatives in the preparation of anti-tumor products, belonging to the technical field of medicine. Background technique [0002] Sodium vitamin C, also known as sodium ascorbate, molecular formula C 6 h 7 NaO 6 (Sodium L-ascorbate). At present, the industry believes that the main mechanism of sodium vitamin C to produce anti-tumor effect is to produce H 2 o 2 It has a killing effect on tumor cells, while the plasma concentration of vitamin C in normal people is only 40-100 μM, which shows that the clinical dosage far exceeds the normal physiological plasma concentration. Existing studies have shown that vitamin C sodium kills renal cancer cells at high doses, inhibits the growth of transplanted tumors of renal cancer, and also inhibits the growth of renal cancer xenografts. 2 o 2 Oxidative damage to normal cells. Therefore, how to ensure the effect of vitamin C sodium on tumor cells withou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/375A61K31/665A61P35/00A61P35/04
CPCA61K31/375A61K31/665
Inventor 慈维敏
Owner BEIJING INST OF GENOMICS CHINESE ACAD OF SCI CHINA NAT CENT FOR BIOINFORMATION
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