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Bear gall powder capable of regulating blood fat, reducing cholesterol, and preventing cardiovascular and cerebrovascular diseases and atherosclerosis

A technology for atherosclerosis and cardiovascular and cerebrovascular diseases, applied in the field of medical and health products, can solve the problems of limiting the application range of bear bile powder, many impurities, unstable properties, etc.

Inactive Publication Date: 2018-10-19
威海森宝实业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] CN1311002A (00102073.0, Shi Lixia) discloses a refined bear bile powder and its preparation method, which belongs to the field of pharmacy. Common bear bile powder is easy to absorb moisture and agglomerate, has a sticky tooth feeling, extremely fishy smell, extremely bitter taste, many impurities, and slow absorption. The nature is unstable and easy to be corrupted, and the content of active ingredients is low, which limits the application scope of bear bile powder. Oral application often adds flavoring agents to reduce the stench

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Embodiment 1: prepare bear bile powder

[0098] (1) filter the bear bile collected by the tubeless drainage method to obtain the filtrate, add 0.75 times of water dilution to obtain bear bile;

[0099] (2) In the mode of bubbling, in step (1) gained bear bile liquid, be charged with nitrogen for 27min, then be charged with carbon dioxide for 18min;

[0100] (3) Pour the bear bile liquid processed through the above operations into the material tray (the depth of the liquid layer is 1.5~2.5cm), and immediately place it in a freeze dryer that has been frozen to -50°C in advance, and freeze it for 3.4 hours; The temperature was raised to -22°C at a rate of 0.3°C and kept for 1 hour; then the temperature was raised to -3°C at a rate of 0.3°C per minute and kept for 2.5 hours; then the temperature was raised to 12°C at a rate of 0.3°C per minute and kept for 4.5 hours; then Raise the temperature to 32°C at a rate of 0.3°C per minute, keep it for 2.5 hours, and end the freez...

Embodiment 2

[0108] Embodiment 2: prepare bear bile powder

[0109] (1) filter the bear bile collected by the tubeless drainage method to obtain the filtrate, add 0.5 times the amount of water to dilute to obtain bear bile;

[0110] (2) In the mode of bubbling, in step (1) gained bear bile liquid, be filled with nitrogen 30min, then be filled with carbon dioxide 15min;

[0111] (3) Pour the bear bile liquid processed through the above operations into the material tray (the depth of the liquid layer is 1.5~2.5cm), and immediately place it in a freeze dryer that has been frozen to -55°C in advance, and freeze it for 3 hours; The temperature was raised to -25°C at a rate of 0.3°C and kept for 1.5 hours; then the temperature was raised to -2°C at a rate of 0.25°C per minute and kept for 2 hours; then the temperature was raised to 10°C at a rate of 0.25°C per minute and kept for 5 hours; then Raise the temperature to 30°C at a rate of 0.25°C per minute, keep it for 3 hours, and end the freez...

Embodiment 3

[0119] Embodiment 3: prepare bear bile powder

[0120] (1) filter the bear bile collected by the tubeless drainage method to obtain the filtrate, add 1 times the amount of water to dilute to obtain bear bile fluid;

[0121] (2) In the mode of bubbling, in step (1) gained bear bile liquid, be filled with nitrogen 25min, then be filled with carbon dioxide 20min;

[0122] (3) Pour the bear bile liquid processed through the above operations into the material tray (the depth of the liquid layer is 1.5~2.5cm), and immediately place it in a freeze dryer that has been frozen to -45°C in advance, and freeze it for 4 hours; The temperature was raised to -20°C at a rate of 0.35°C and kept for 1.25 hours; then the temperature was raised to -3°C at a rate of 0.35°C per minute and kept for 3 hours; then the temperature was raised to 15°C at a rate of 0.35°C per minute and kept for 4 hours; Raise the temperature to 35°C at a rate of 0.35°C per minute, keep it for 2 hours, and end the free...

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Abstract

The invention discloses bear gall powder capable of regulating blood fat, reducing cholesterol, and preventing cardiovascular and cerebrovascular diseases and atherosclerosis, a preparation method ofthe bear gall powder, and applications of the bear gall powder in preparation of products used for regulating blood fat, reducing total cholesterol, and preventing cardiovascular and cerebrovascular diseases and atherosclerosis. In the preparation process, material ice crystallization and freeze drying are adopted, so that the ice crystallized bear gall powder is obtained. No accessory ingredientor chemical additive is contained by a novel generation of Senbao bear gall powder. The ice crystallized bear gall powder is capable of regulating blood fat, reducing total cholesterol, and preventingcardiovascular and cerebrovascular diseases and atherosclerosis effectively.

Description

technical field [0001] The invention belongs to the technical field of medical and health products, relates to a bear bile powder prepared by a specific process, and also relates to a preparation method of the bear bile powder. The present invention is by making material ice crystallization in the preparation process of bear bile powder followed by freeze-drying, and the prepared bear bile powder presents excellent technical effects, especially such as presenting excellent technical effects aspect physicochemical properties. In particular, the present invention pre-dilutes the bear bile powder with a small amount of water, fills it with two kinds of gas, and carries out deep freezing, so that the active ingredients contained in the bear bile are in a state of ice crystals, and then sublimated, so that the obtained freeze-dried Bear bile powder can be referred to as ice crystal state bear bile powder in the present invention, or can be called ice crystal bear bile powder. Espe...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61P3/06A61P9/10A61P9/00A23L33/10
CPCA61K35/413A23L33/10A23V2002/00A61P3/06A61P9/00A61P9/10A23V2200/3262A23V2200/326
Inventor 齐光伟
Owner 威海森宝实业有限公司
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