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A kind of meloxicam tablet for pet

A technology of meloxicam tablets and loxicam tablets, which is applied in the field of meloxicam tablets for pets, can solve the problems of poor solubility of meloxicam and achieve the effect of increasing blood drug concentration

Active Publication Date: 2020-03-31
JIANGSU HFQ BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the problem of poor solubility of meloxicam in the prior art, the present invention provides a micronized meloxicam tablet with suitable solubility and a preparation method thereof

Method used

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  • A kind of meloxicam tablet for pet
  • A kind of meloxicam tablet for pet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of embodiment 1 meloxicam tablet

[0024] 1. Ingredients

[0025] (1) Meloxicam micronization treatment: Use a mechanical pulverizer to ultrafinely pulverize the meloxicam raw material, collect the pulverized raw material particles, and use a Malvern laser particle size analyzer to measure the particle size of the micropowder. The particle size is below 30 μm,

[0026] (2) Sieving: In the 300,000-level environment, the raw and auxiliary materials are passed through a 60-mesh sieve to remove agglomerates and obtain uniform particle groups.

[0027] (3) Pre-mixing: In the 300,000-level environment, weigh microcrystalline cellulose, sodium citrate, meloxicam, yellow iron oxide, brown iron oxide, red iron oxide, beef essence, Silicone, pregelatinized starch, put it in a high-speed wet mixing granulator, start shearing and stirring, and mix for 10 minutes

[0028] (4) Total blending: In the 300,000-level district environment, weigh the prescribed am...

Embodiment 2

[0047] The preparation method of embodiment 2 meloxicam tablet

[0048] Preparation method 2. (1) Meloxicam micronization treatment: use a jet mill to ultrafinely pulverize the meloxicam raw material, collect the pulverized raw material particles, and use a Malvern laser particle size analyzer to measure the particle size of the micropowder, 90 The particle size at % cumulative volume is below 20 μm. Other parts are with embodiment 1.

Embodiment 3

[0049] The preparation method of embodiment 3 meloxicam tablet

[0050] Preparation method 2. (1) Micronization treatment of meloxicam: (A) pre-crushing meloxicam with a fluid energy mill using collision technology to make particles with a particle size of 80 μm,

[0051] (B) adopt CWJ-30 type superfine pulverizer to carry out superfine pulverization to the above-mentioned coarse particles, pulverize into 5-10 μ m fine powder,

[0052] Grinding conditions: the air temperature after freeze-drying is 6°C, the water content is 0.5%, the pressure when injected into the ultrafine pulverizer is 0.8MPa, the working pressure of the ultrafine pulverizer is 0.8MPa, the internal working temperature is 6°C, and the pulverization time is 50min.

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Abstract

The present invention relates to a meloxicam tablet for pets, comprising 0.15 to 0.25% of micronized meloxicam. The meloxicam pharmaceutical tablet for pets comprises the following weight percentages of raw materials: 0.15 to 0.25% of micronized meloxicam, 75 to 85% of a filler, 5 to 10% of a flocculant, 5 to 15% of a flavouring agent, 0.5 to 1.5% of a lubricant, and 0.5 to 1.5% of a toner. The pharmaceutical composition of micronized meloxicam obtained by the method of the present invention not only maintains all effective constituent of the active pharmaceutical ingredient, but also achieves maximum blood concentration rapidly after oral administration of the medicament and improves bioavailability due to micronization and addition of the flocculant.

Description

technical field [0001] The invention belongs to the technical field of veterinary pharmacy, and in particular relates to a meloxicam tablet for pets. Background technique [0002] Meloxicam (Meloxicam, C 14 h 13 N 3 o 4 S 2 ) is a non-steroidal anti-inflammatory drug, mainly used in animal husbandry and pet breeding. At present, meloxicam has been widely used in the treatment of inflammation and pain diseases at home and abroad. In particular, meloxicam has better gastrointestinal and renal tolerance than other drugs of the same type, and can effectively treat rheumatoid arthritis, osteoarthritis and other inflammatory diseases. [0003] However, since meloxicam is insoluble in water, it is impossible to administer medicine to livestock and poultry in the form of mixed drink. Although the oral liquid and water-soluble granules of meloxicam are available now, the water solubility has been improved to a certain extent or it can be taken orally or mixed for drinking. Ho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5415A61K9/20A61K47/38A61P29/00A61P19/02
CPCA61K9/2054A61K9/2059A61K31/5415A61P19/02A61P29/00A61K9/0053
Inventor 廖洪武慧芳陈洁
Owner JIANGSU HFQ BIO TECH CO LTD
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