Antitumor drug and antitumor external application drug, and preparation methods thereof

Abstract

The invention discloses an antitumor drug and an antitumor external application drug, and preparation methods thereof. Raw materials of the antitumor drug include a protein antitumor biomaterial containing at least one group of -OH, -COOH and -NH2, a photocoupler and a solvent; the photocoupler includes an aromatic azide. The preparation process includes that the protein antitumor biomaterial, thephotocoupler and the solvent are subjected to mixed reaction under light shielding conditions. The photocoupler aromatic azide is used as a modifier to modify the protein antitumor biomaterial, and the preparation method has the advantages of low cost, good modification effect, high yield and wide application range. The synthesized antitumor drug contains azidophenyl, has photosensitive activityand can be fixed on medical dressings through photochemistry to form the antitumor external application drug; the drugs are closely linked and not easy to fall off, death induction signals can be continuously sent to tumor cells, the action time of the drugs is prolonged, and the therapeutic effect is improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an anti-tumor drug, an anti-tumor drug for external application and a preparation method thereof. Background technique [0002] Biomedical materials (also known as biomaterials) are a class of new high-tech materials used to diagnose, treat, repair or replace human tissues and organs or enhance their functions. With the development of society and economy, the injection of new technologies has made biological The medical materials industry continues to develop with an annual growth rate of more than 20%. The successful clinical application of biomaterials has saved the lives of tens of millions of critically ill patients, and has significantly reduced the mortality of cardiovascular diseases, cancer, and other major diseases. It played an important role. The physical and chemical modification of the surface of biomaterials plays an important role in the development of new medic...

AI Technical Summary

Problems solved by technology

However, in the existing anti-tumor biomaterial modification, the cost of the modifier used is high, the modification effect is not ideal, and the application range is narrow; and physical adsorption modification is usually used, the modification process is complicated, the yield is low, and it is difficult to achieve large-scale production

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