Application of simulated fasting diet in the prevention and treatment of Parkinson's disease

A Parkinson's disease, heat technology, applied in the field of medical neurology, can solve the problems of PD mice with no therapeutic effect, worsening dysfunction, and low operability, and achieve the increase in the number of tyrosine hydroxylase-positive neuron cells , Improve the symptoms of slow movement, improve the effect of dopamine content

Active Publication Date: 2022-08-09
JIANGNAN UNIV
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  • Abstract
  • Description
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Problems solved by technology

[0004] Studies have shown that other dietary interventions, such as caloric restriction (30% caloric restriction), have a relieving effect on PD mammalian models, but William et al. showed that 40% caloric restriction has no therapeutic effect on MPTP-induced PD mice At the same time, there are also literatures showing that fasting every other day (every 24 hours) has no significant effect on PD rats
However, for most people, either caloric restriction or alternate-day fasting is less maneuverable and its extreme nature may cause adverse effects, including worsening malnutrition and functional impairment, especially in older age for people and the infirm

Method used

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  • Application of simulated fasting diet in the prevention and treatment of Parkinson's disease
  • Application of simulated fasting diet in the prevention and treatment of Parkinson's disease
  • Application of simulated fasting diet in the prevention and treatment of Parkinson's disease

Examples

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Embodiment 1

[0032] Example 1: Establishment and grouping of animal models

[0033] Body weight 20-25g, 7-week-old, male C57BL / 6J mice were randomly divided into blank control group (NS-AL group, ad libitum and intraperitoneal injection of normal saline), blank diet group (NS-FMD group, simulated fasting diet and Intraperitoneal injection of normal saline), model group (MPTP-AL group, free feeding and intraperitoneal injection of MPTP), treatment group (MPTP-FMD group, simulated fasting diet and intraperitoneal injection of MPTP), 20 animals in each group. The animals were placed at 23±2°C, and the lighting time was 12 hours / day, and the animals were acclimated to the environment for one week before dietary intervention. The NS-FMD group and the MPTP-FMD group were given FMD diet for three consecutive weeks, and on the last day of the second week, 0.9% saline or MPTP were injected intraperitoneally with MPTP (20 mg / kg) for four consecutive times, each time interval 2 hours. Both the NS-AL...

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Abstract

The invention discloses the application of simulated fasting diet in preventing and treating Parkinson's disease, and belongs to the technical field of medical neurology. After establishing a Parkinson's disease animal model, the present invention comprehensively uses various research methods such as behavioral, immunological, biochemical indicators, etc., and experiments confirm that the drug can improve the movement disorder symptoms of Parkinson's disease model mice; reduce dopamine in the substantia nigra pars compacta neuron loss. The simulated fasting diet has strong operability and good effect, so it has certain development value and prospect in clinical application.

Description

technical field [0001] The invention relates to the application of simulated fasting diet in preventing and treating Parkinson's disease, and belongs to the technical field of medical neurology. Background technique [0002] Parkinson's disease (PD) is the most common degenerative disease of the motor nervous system. The main clinical manifestations are: resting tremor, bradykinesia, unsteadiness, postural reflex disorders, and non-motor symptoms such as dysbacteriosis and constipation. The main lesions in the brain of PD patients are the substantia nigra and striatum. The degeneration and death of dopaminergic (DA) neurons in the substantia nigra pars compacta is the direct cause of the decrease in dopamine projection into the striatum. The pathogenesis of PD is still unclear, but a large number of studies have shown that its occurrence interacts with pathological mechanisms such as oxidative stress injury, immune inflammation, apoptosis, and autophagy. Recent studies have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K50/50A23K10/30A23K10/37A23K20/147A23K20/158A23K10/18A23K20/22A23K20/142A23K20/20A23K20/24A23K20/174A01K67/02
CPCA01K67/02A23K10/18A23K10/30A23K10/37A23K20/142A23K20/147A23K20/158A23K20/174A23K20/20A23K20/22A23K20/24A23K20/30A23K50/50A01K2267/0318A01K2227/105Y02P60/87
Inventor 申延琴周芝兰崔春孙孟菲陈雪
Owner JIANGNAN UNIV
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