Application of fasting mimicking diet in prevention and treatment of Parkinson's disease

Abstract

The invention discloses application of a fasting mimicking diet in prevention and treatment of Parkinson's disease and belongs to the technical field of medical neurology. According to the application, an animal model of Parkinson's disease is built; multiple research methods such as behavioristics, immunology and biochemical indexes are comprehensively used; experiments prove that the medicine iscapable of improving dyskinesia symptoms of model mice of Parkinson's disease and reducing loss of dopamine neurons in the pars compact of substantia nigra; the fasting mimicking diet is high in operability and excellent in effect, and has certain development values and prospects in clinical application.

Description

technical field [0001] The invention relates to the application of simulated fasting diet in the prevention and treatment of Parkinson's disease, and belongs to the technical field of medical neurology. Background technique [0002] Parkinson's disease (PD) is the most common degenerative disease of the motor nervous system. The main clinical manifestations are: resting tremor, slow movement, unsteady standing, postural reflex disorder, flora imbalance, constipation and other non-motor symptoms. The main lesions in the brain of PD patients are the substantia nigra and striatum, and the degeneration and death of dopamine (DA) neurons in the substantia nigra compacta is the direct cause of the decrease of dopamine projected to the striatum. The pathogenesis of PD is currently unclear, but a large number of studies have shown that its occurrence interacts with pathological mechanisms such as oxidative stress injury, immune inflammation, apoptosis, and autophagy. Recent studies ...

AI Technical Summary

Problems solved by technology

[0004] Studies have shown that other dietary interventions, such as caloric restriction (30% caloric restriction), have a relieving effect on PD mammalian models, but William et al. showed that 40% caloric restriction has no therapeutic effect on MPTP-induced PD mice At the same time, there are also literatures showing that fasting every other day (every 24 hours) has no significant effect on PD rats

However, for most people, either caloric restriction or alternate-day fasting is less maneuverable and its extreme nature may cause adverse effects, including worsening malnutrition and functional impairment, especially in older age for people and the infirm

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