A kind of rosiglitazone saccharin salt and preparation method thereof

A technology for rosiglitazone and saccharin salt, which is applied in the field of rosiglitazone saccharin salt and its preparation, can solve the problems of high price and limited clinical application, and achieves the advantages of good reproducibility, improved taste and easy control of crystallization process. Effect
CN109053718BActive Publication Date: 2022-06-03TIANJIN UNIVERSITY OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN UNIVERSITY OF TECHNOLOGY
Publication Date
2022-06-03

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Abstract

The invention discloses a saccharin salt of rosiglitazone and a preparation method thereof. This rosiglitazone saccharin salt contains rosiglitazone cation and saccharin anion in a molar ratio of 1:1. At the same time, the preparation method of the rosiglitazone saccharin salt is also disclosed. The rosiglitazone saccharin salt is reacted in a solvent, and the rosiglitazone saccharin salt is obtained by stirring, ultrasonication, volatilization or cooling crystallization. The present invention provides a brand-new rosiglitazone saccharin salt, which has obvious advantages in the dissolution property and taste improvement of the drug, and can be applied in the pharmaceutical industry, and the preparation method is simple and the crystallization process is simple. Easy to control, good reproducibility, suitable for industrial production.
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Description

A kind of rosiglitazone saccharin salt and preparation method thereof technical field The present invention relates to chemical medicine field, particularly a kind of rosiglitazone saccharin salt and preparation method thereof. Background technique

[0002] Pharmaceutically active ingredients typically exist in crystalline forms such as polymorphs, hydrates, solvates, co-crystals, salts, and the like. right For the same drug active ingredient, different crystalline forms have different physicochemical properties. Therefore, in the pharmaceutical industry, the It is of great significance to obtain the appropriate crystalline form of the drug. The drug exists in the form of a salt, which can improve the stability of the active ingredient of the drug. It has significant advantages in terms of qualitative and increased solubility. Therefore, in terms of improving the physicochemical properties of active pharmaceutical ingredients, drugs The salt form is usually the fir...

Claims

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