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A kind of rosiglitazone saccharin salt and preparation method thereof

A technology for rosiglitazone and saccharin salt, which is applied in the field of rosiglitazone saccharin salt and its preparation, can solve the problems of high price and limited clinical application, and achieves the advantages of good reproducibility, improved taste and easy control of crystallization process. Effect

Active Publication Date: 2022-06-03
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Since the rosiglitazone currently used in China is mostly imported, the price is expensive, and the average patient cannot bear it, so that the clinical application is limited

Method used

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  • A kind of rosiglitazone saccharin salt and preparation method thereof
  • A kind of rosiglitazone saccharin salt and preparation method thereof
  • A kind of rosiglitazone saccharin salt and preparation method thereof

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preparation example Construction

[0047] Further, alcohol solvents include but are not limited to methanol, ethanol, isopropanol.

[0051] Further, the nitrile solvent includes but is not limited to acetonitrile.

[0053] A pharmaceutical composition comprising the rosiglitazone saccharin salt.

[0054] Preferably, a pharmaceutical composition, including this rosiglitazone saccharin salt and a pharmaceutically acceptable excipient.

Embodiment 1

Embodiment 2

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Abstract

The invention discloses a saccharin salt of rosiglitazone and a preparation method thereof. This rosiglitazone saccharin salt contains rosiglitazone cation and saccharin anion in a molar ratio of 1:1. At the same time, the preparation method of the rosiglitazone saccharin salt is also disclosed. The rosiglitazone saccharin salt is reacted in a solvent, and the rosiglitazone saccharin salt is obtained by stirring, ultrasonication, volatilization or cooling crystallization. The present invention provides a brand-new rosiglitazone saccharin salt, which has obvious advantages in the dissolution property and taste improvement of the drug, and can be applied in the pharmaceutical industry, and the preparation method is simple and the crystallization process is simple. Easy to control, good reproducibility, suitable for industrial production.

Description

A kind of rosiglitazone saccharin salt and preparation method thereof technical field The present invention relates to chemical medicine field, particularly a kind of rosiglitazone saccharin salt and preparation method thereof. Background technique [0002] Pharmaceutically active ingredients typically exist in crystalline forms such as polymorphs, hydrates, solvates, co-crystals, salts, and the like. right For the same drug active ingredient, different crystalline forms have different physicochemical properties. Therefore, in the pharmaceutical industry, the It is of great significance to obtain the appropriate crystalline form of the drug. The drug exists in the form of a salt, which can improve the stability of the active ingredient of the drug. It has significant advantages in terms of qualitative and increased solubility. Therefore, in terms of improving the physicochemical properties of active pharmaceutical ingredients, drugs The salt form is usually the fir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D417/12C07D275/06A61P3/10A61P3/06A61P9/12A61P9/00A61P1/00A61K31/4439A61K47/22
CPCA61K47/22A61P1/00A61P3/06A61P3/10A61P9/00A61P9/12A61K31/4439C07D275/06C07D417/12C07B2200/13
Inventor 陈嘉媚袁玫鲁统部
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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