Weight losing tablet containing orlistat
A technology of orlistat and slimming tablets, which is applied in the field of medicine, can solve problems such as poor fluidity, low dissolution rate, slow progress, etc., and achieve the effect of avoiding thermal decomposition, avoiding damp heat decomposition, and improving dissolution rate
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Embodiment 1
[0074] Example 1 Preparation of 60 mg specification orlistat tablet (unit: g)
[0075]
[0076] Preparation Process:
[0077] Step 1. Take orlistat and microcrystalline cellulose, pulverize them, pass through a 100-mesh sieve, and set aside;
[0078] Step 2. Take the prescribed amount of orlistat, microcrystalline cellulose, polymer, and colloidal silicon dioxide, put them in a turbulent flow mixer, and mix for about 4 minutes;
[0079] Step 3: Continuously feed the mixed material at a certain rate, and continuously extrude the twin-screw extruder through an orifice with a certain aperture at a melt temperature of 45° C. to obtain a strip-shaped semi-solid intermediate;
[0080] Step 4, cutting the strip intermediate obtained in step 3 according to a certain thickness to obtain orlistat tablets;
[0081] Step 5: Packing the orlistat tablet obtained in step 4 with PVDC / aluminum foil having high moisture-proof performance as the packaging material to obtain a finished produ...
Embodiment 2
[0082] Example 2 Preparation of 120mg Orlistat Tablets (Unit: g)
[0083]
[0084]
[0085] Preparation Process:
[0086] Step 1. Take orlistat and microcrystalline cellulose, pulverize them, pass through a 100-mesh sieve, and set aside;
[0087] Step 2. Take the prescribed amount of orlistat, microcrystalline cellulose, polymer, and colloidal silicon dioxide, put them in a turbulent flow mixer, and mix for about 4 minutes;
[0088] Step 3: Continuously feed the mixed material at a certain rate, and continuously extrude the twin-screw extruder through an orifice with a certain aperture at a melt temperature of 45° C. to obtain a strip-shaped semi-solid intermediate;
[0089] Step 4, cutting the strip intermediate obtained in step 3 according to a certain thickness to obtain orlistat tablets;
[0090] Step 5: Packing the orlistat tablet obtained in step 4 with PVDC / aluminum foil having high moisture-proof performance as the packaging material to obtain a finished produc...
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