Florfenicol nanoemulsion and preparation method thereof

Abstract

The invention discloses florfenicol nano-emulsion and a preparation method thereof. The florfenicol nano-emulsion comprises florfenicol, N,N-dimethylformamide, olive oil, EL-40, glycerine, and distilled water. The preparation method thereof comprises the following steps: enabling the florfenicol to be dissolved in the N,N-dimethylformamide, adding the olive oil, the EL-40 and the glycerine and uniformly mixing, dropwise adding the distilled water while stirring, to obtain the florfenicol nano-emulsion. The provided florfenicol nano-emulsion is an O / W type, clarified and transparent, and can bemixed with the water in arbitrary proportions. An average particle size is 28 nm, and a Zeta potential is -0.45 mV. A size of an emulsion ball is uniform and non-adhered, and stable. The antibacterial effect is good. The florfenicol nano-emulsion has an extremely high application value in livestock breeding.

Description

technical field [0001] The invention relates to the field of veterinary drug preparation, in particular to a florfenicol nanoemulsion and a preparation method thereof. Background technique [0002] Florfenicol is a fluorinated derivative of fluthiamphenicol, a broad-spectrum antibacterial drug for animals in the class of chloramphenicol, and is widely used in the field of veterinary medicine. Florfenicol has a smaller minimum inhibitory concentration (MIC) than chloramphenicol, and will not cause aplastic anemia, so it can be used as an ideal substitute drug for chloramphenicol, and has been widely used in cattle, Prevention and treatment of bacterial diseases in pigs, poultry and aquatic animals. Florfenicol has poor water solubility and is easily hydrolyzed under acidic conditions. The dissolution of common oral preparations in the gastrointestinal tract is relatively slow. At present, premix and powder are the main dosage forms of Florfenicol on the market, resulting in ...

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Problems solved by technology

[0004] Liu Angang et al. (Preparation and quality evaluation of florfenicol nanoemulsion [J]. Northwest Agricultural Journal, 2011, 20(05): 44-49.) used Tween-80 as surfactant and glycerin as surfactant by magnetic stirring method. The co-surfactant and ethyl acetate are the oil phase, and the ratio of each component is 6:3:1. The particle size range of the prepared florfenicol nanoemulsion is 5-70 nm, and the average particle size is 30 nm; Zhu Shuhui et al. (Research on the preparation and properties of florfenicol nanoemulsion [J]. Heilongjiang Animal Husbandry and Veterinary Medicine, 2018(03): 209-211+261.) The excipients used are similar to those of Liu Angang, and ethanol is added to the co-surfactant. The particle size range of the Florfenicol nanoemulsion prepared by the high-pressure homogenization technique is 35-95 nm, and the average particle size is 60 nm; patent CN103800288A and patent CN105125490A both disclose the preparation method of Florfenicol nanoemulsion, but the former obtains Emulsion particle diameter is less than 220nm, and the Florfenicol nanoemulsion particle diameter that the latter obtains is distributed between 20nm-65nm, and average particle diameter is 40nm; The large distribution range is not conducive to the tolerance of livestock and poultry. In the patent CN105125490A prescription, a relatively high concentration of ethanol is used. If the florfenicol nanoemulsion is used as an oral preparation, there will be problems of strong odor and poor taste, resulting in It is difficult to administer drugs to animals; if it is used as an injection preparation, it is easy to cause greater irritation. In view of the above reasons, it is not suitable for use as a veterinary preparation

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