75results about How to "Avoid rejection" patented technology

The invention provides a method for constructing tissue engineering skin. In the method, human epidermal stem cells and hypodermal fibroblasts are taken as seed cells, and a homologous acellular dermal matrix modified by a human placental type IV collagen is taken as a stent, so that active dual-layer engineering skin is compounded and constructed by using a gas-liquid interface separate culture method. The tissue engineering skin constructed by using the method is closer to the structure of natural skin; and as proved by histomorphology, the tissue engineering skin has an epidermal and hypodermal double-layer structure, wherein the hypodermal collagen stent has a complete structure, an epidermal layer is provided with a plurality of layers of cells of different differentiation degrees, and the morphological requirement of the tissue engineering skin is met.

In order to improve an implant for replacing a vertebral body or for insertion into an intervertebral cavity between adjacent vertebral bodies of a human or animal spinal column, with a first contact face for resting on a joint face of a first vertebral body and with a second contact face for resting on a joint face of a second vertebral body, the implant being at least partially produced from an X-ray transparent material and comprising at least one X-ray marker in such a way that it can be produced more simply, it is proposed that the at least one X-ray marker is configured in the form of an at least partial marker coating, which contains metal as the marker material, of a side face of the implant, which is inclined relative to the first and/or the second contact face by an angle of inclination.

The invention belongs to the fields of genetic engineering and synthetic biology, and in particular relates to general type CART/TCRT cells with antibody drug resistance as well as a construction method of the general type CART/TCRT cells. The general type CART/TCRT cells are allogeneic T cells having chimeric antigen receptors and T cell receptors, and alpha and beta chains and CD52 molecules ofthe T cell receptors are knocked out; a technology for knocking out the alpha and beta chains and the CD52 molecules of the T cell receptors is a CRISPR technology; the general type CART/TCRT cells not only retain the targeting of tumor specific antigen, but also eliminate the problems of GvHD and rejection, and weaken the sensitivity to an antibody drug Alemtuzumab; the general type CART/TCRT cells can be used as a general type simple, low-cost and high-activity CART/TCRT cell preparation.

The invention relates to medical human body wound drainage consumables and provides a three-cavity negative-pressure wound irrigation and drainage tube. The negative-pressure wound irrigation and drainage tube comprises an in-vivo drainage tube and an in-vitro connection tube, wherein the in-vivo drainage tube adopts an integral structure and is provided with a main drainage tube, an irrigation tube and a guide wire implanting tube which are parallelly arranged lengthways; the main drainage tube is arranged in the geometric center of the in-vivo drainage tube, and the irrigation tube and the guide wire implanting tube are located at the periphery of the main drainage tube; a lower groove is formed in the outer wall of the in-vivo drainage tube, and a plurality of drainage openings are formed in the lower groove and communicated with the main drainage tube; the in-vitro connection tube comprises an in-vitro drainage tube, an in-vitro irrigation tube and an in-vitro guide wire implanting tube which are mutually independent; the in-vitro drainage tube, the in-vitro irrigation tube and the in-vitro guide wire implanting tube are respectively communicated with the main drainage tube, the irrigation tube and the guide wire implanting tube which are arranged at the outer end of the in-vivo drainage tube. The three-cavity negative-pressure wound irrigation and drainage tube mainly adopts a three-cavity structure, is used for drainage of wounds deep in a human body and has the effects of being accurate in implanting, favorable in drainage and irrigation, resistant to blockage, and the like.

The invention belongs to the field of biomedicine and particularly relates to soluble human keratin and application thereof. The soluble keratin is obtained through the following process of cloning amiddle sequence of a human gene K37, constructing a recombinant vector, transforming bacteria, inducing expression of the recombinant protein and purifying the recombinant protein to obtain the soluble keratin. The soluble keratin has the characteristic of rapid swelling and can promote mitosis and migration of epidermal cells, and therefore the soluble keratin can be used for preparing biologicalmaterials or medicaments for promoting cell proliferation or migration, and plays a role in hemostasis and wound healing. Moreover, the soluble keratin causes no rejection phenomenon when being usedfor the human body, is safe to use and thus has a wide application prospect in the field of biomedicine.

The invention relates to the field of medical treatment, and in particular relates to a keratoprosthesi. The keratoprosthesis comprises a frame and a cylindrical lens, wherein the frame is of a shape of a smaller part of a spherical surface which is cut off by a reference surface, and the center of the frame is provided with a central hole; the inner wall of the central hole is provided with internal threads; the frame comprises a main body and a metal net which is embedded in the main body; the extension direction of the metal net is consistent with the extension direction of the main body; and the outer wall of the cylindrical lens is provided with external threads which are matched with the internal threads. Compared with the prior art, according to the keratoprosthesi, the frame is designed in the way of comprising two parts of the main body and the metal net which is embedded in the main body, and because the human eye tissue and medical resin have higher compatibility, the human eye tissue can grow together with the main body, and cannot slowly push the main body to move towards the outside; but the medical resin material is crisper and lower structural strength, the structural strength of the frame can be improved through embedding the metal net into the frame, so the frame is not easy to be damaged.

The invention discloses an implantable biological brain electrode multi-stage propulsion system and an operation method thereof. A bioelectrode is three-stage advancement, and comprises a positioningstage, an advancement stage and a conductive stage in turn. The positioning stage is used to fix the position of the electrode body and break through endocraniums and arachnoids. The tip reaches the outside of the arachnoids, so as to prevent inflammatory reaction caused by damaged tissues brought into the cerebral cortex by the electrode. The advancement stage is used to carry the conductive stage to a target implantation site in the cortex. The conductive stage is made of a core wire and a conductive biomaterial. A communicated porous structure is inside the conductive biomaterial. Nerve inducing factors are perfused onto the porous conductive biomaterial to realize inducing nerve cell synapse ingrowth and electroneurographic signal acquisition. Based on a biological neural interface made of a natural material, natural coupling and functional transition from a biologically active neural network organization to an information sensing device can be realized through the induction of nerve cell synapses, and technical and model foundations are provided for the perfect transition of a brain instruction terminal and an external information acquisition terminal.

The invention relates to the field of cell culture and particularly relates to a whole eye cornea bioengineering cultivation method. The various layers of the cornea are respectively cultivated, and the advantage is that only a cornea layer needed by a patient is cultivated when the patient does not need the transplantation of the whole cornea. According to the provided preparation method of the whole cornea, a seed cell between the cornea epidermal layer and a mesenchymal layer is an autologous cell, a corneal endothelial cell is from a donator, a large quantity of endothelial cells are obtained through cultivation, and the limit of the source of the donator is avoided. A collagen culture medium is taken as a gluing medium between the epidermal layer and the mesenchymal layer, and the intraneural growth of the human bioengineering cornea is promoted. The provided whole cornea and partial cornea both have an excellent optical property, the patients all recovers the eyesight after the operation, the cornea has a stable biochemical characteristic, the dissolution of the cornea in the later period does not exist, the biocompatibility is excellent, and no rejection reaction is caused.

The invention discloses a device and a method for realizing automatic bus transferring actions of a three-wire three-change enlarged inner bridge wiring transformer substation. The device mainly comprises three power circuits L1, L2 and L3, three transformers which comprise a first transformer, a second transformer and a third transformer respectively, three buses which comprise a first bus, a second bus and a third bus, and breaker switches 1DL to 5DL. According to the device and the method for realizing automatic bus transferring actions of the three-wire three-change enlarged inner bridge wiring transformer substation disclosed by the invention, simple and practical logic of the automatic bus transferring actions can be realized, the action reliability is higher than that of a traditional inner bridge wiring single automatic bus transferring device, and conditions of refused actions and false actions of the automatic bus transferring device can be prevented effectively.

The invention discloses a preparation method of a lymphoma-targeted blood platelet targeting drug loading system which carries and loads a CD22 monoclonal antibody and an anti-tumor drug. The preparation method comprises the following steps: firstly deeply centrifuging and washing blood platelet-enriched blood plasma obtained through whole blood anticoagulation and centrifugation, obtaining washed blood platelets, treating a maleimide group with the surface modified with a pointing sulfhydryl by adopting an MBS reagent, and then reacting with an anti-CD22 monoclonal antibody subjected to sulfhydrylation by virtue of a Traut's reagent, so that the blood platelets which connect the CD22 monoclonal antibody and target lymphoma cells are obtained; and then carrying out mixed incubation on the blood platelets and the anti-tumor drug, centrifuging, and dispersing, so that the target drug loading system is obtained finally. The drug loading system has the advantages of wide source, high drug loading ratio, good biocompatibility, active and accurate targeting, long cycling time and the like, the anti-tumor effect of the drug can be enhanced, and the toxicity on normal tissues is also reduced, so that toxic and side effects of a chemotherapy drug are alleviated, and the drug loading system is significant for improving the life quality and medical quality of a patient with lymphoma.

Provided is an attachment reconstructive artificial rotator cuff patch and a manufacture method thereof. The method comprises the following steps that a patch intermediate layer with a nanofiber structure is constructed through electrostatic spinning, or a patch intermediate layer with a meshy fabric body structure is constructed by weaving, and the patch intermediate layer with a nanofiber structure or the patch intermediate layer with the meshy fabric body structure serves as a supporting body of the whole patch; the two ends of the patch intermediate layer are respectively a muscle tendon part and an attachment part, a patch muscle tendon part intermediate layer wraps and crosslinks on the muscle tendon part of the patch intermediate layer, and a patch attachment part intermediate layerwraps and crosslinks on the attachment part of the patch intermediate layer; the upper surfaces of the patch muscle tendon part intermediate layer and patch attachment part intermediate layer are correspondingly coated and crosslinked with patch upper layers, and the lower surfaces of the patch muscle tendon part intermediate layer and patch attachment part intermediate layer are correspondinglycoated and crosslinked with patch muscle tendon part lower layers and patch attachment part lower layers to form the whole attachment reconstructive artificial rotator cuff patch. The provided rotatorcuff patch can repair rotator cuff coloboma and reconstruct tendon-bone attachment, and has good mechanical strength and good biocompatibility.

The invention discloses a polarity tester of a current transformer, and relates to the technical field of polarity testing of the current transformer. The tester is provided with a shell, wherein a detection circuit is arranged in the shell and comprises a signal access circuit, a signal processing circuit and a signal indicating circuit; the signal access circuit is connected with a secondary side of the current transformer for outputting positive peak voltage and negative peak voltage; the signal processing circuit is connected with the signal access circuit for converting the positive peak voltage and the negative peak voltage into +5V voltage respectively; and the signal indicating circuit is connected with the signal processing circuit for indicating the polarity of the current transformer. The polarity tester has the advantages of time saving, labor saving, economy, practicability and capability of bringing great convenience for polarity testing of the current transformer.

A synthetic bone substitute has a porous foam structure comprising a bio-resorbable polymer and a bio-ceramic filler material. A plasticizer is used for softening the porous foam structure such that the synthetic bone substitute may be compressed by an external force. Due to its elasticity, the synthetic bone substitute may restore its original form after releasing the external force. Furthermore, due to dissipation of the plasticizer, the porous foam structure can attain substantial rigidity thereby functioning as lightweight, stable bone substitute. Such a compressible bone substitute can be compressed, then inserted through a small opening hole to a cavity and once in a cavity restore its original volume and rigidity.

The invention provides a number changing service processing method and device, and the method comprises the steps: determining whether a first number has a corresponding third number or not when obtaining a communication request between the first number and a second number; when it is determined that the third number exists in the first number, obtaining a number changing notification list corresponding to the first number or the third number; and when it is determined that the second number is in the number changing notification list, changing the first number into a third number to completecommunication. According to the number changing service processing method and device provided by the embodiment of the invention, when the communication request between the first number and the secondnumber is obtained, whether the first number has the corresponding third number is determined; when it is determined that the third number exists in the first number, a number changing notification list corresponding to the first number or the third number is obtained; and when it is determined that the second number is in the number changing notification list, the first number is changed into the third number to complete communication, thereby avoiding the refusing of a frequent contact, and optimizing the call contact.

The invention relates to a preparation method and application of a silk fibroin compound hydroxyapatite material. The preparation method comprises the following steps: 1, preparing a silk fibroin aqueous solution, and performing concentration; 2, preparing a mixed solution from the silk fibroin aqueous solution with a horseradish peroxidase solution and hydrogen peroxide; 3, molding the mixed solution, performing crosslinking in an environment at the temperature of 28-45 DEG C, and performing freezing treatment to obtain a silk fibroin primary molding product; 4, soaking the silk fibroin primary molding product in a methanol solution, performing rinsing to obtain silk fibroin molding product; and 5, synthesizing nano-hydroxyapatite particles on the silk fibroin molding product by using anin-situ mineralization method to obtain the silk fibroin compound hydroxyapatite material. The preparation method can prepare silk fibroin compound hydroxyapatite bone duct by adopting a method with simple operation, high yield and no toxicity, and the silk fibroin compound hydroxyapatite bone duct can be used for effectively treating continuous bone defects and can avoid risks in autogenous boneextraction and rejection reaction of allogeneic bones.

The invention provides a valve control system and method, relates to the field of automatic control, and solves the problem that an existing pressure valve is prone to refuse to operate. The system comprises pressure detection devices, a first control device, a second control device and a pressure valve, wherein one pressure detection device is connected with the pressure valve through the first control device, and the other pressure detection device is connected with the pressure valve through the second control device. The valve control system and method are used for controlling the valve to be opened and closed.