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Degradeable composite artificial esophagus and preparing method thereof

An esophagus, artificial technology, applied in the direction of the device of the human tubular structure, etc., can solve the problems of incomplete epithelialization of the esophagus cavity, poor collagen strength, incomplete regeneration of esophageal tissue, etc., to promote epithelial and interstitial adhesion and growth. , Anti-shrinkage and anti-tear effect, the effect of avoiding tissue rejection

Inactive Publication Date: 2004-09-15
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, artificial esophagus is mostly made of silicone rubber, Teflon, carbon fiber, etc., but due to poor compatibility between materials and tissues, blood vessels and tissues cannot grow in, and the esophageal lumen cannot be completely epithelialized, resulting in esophageal tissue regeneration. Incomplete, resulting in serious complications such as infection, anastomotic leakage, anastomotic stenosis, artificial esophagus that cannot be fixed biologically, and eventually falls off inevitably
After literature search, it is found that the US patent application number: US 6241774, name: "Artificial esophagus" (artificial esophagus), this patent introduces the method of preparing a composite artificial esophagus by soaking medical silicone rubber in a collagen solution and then undergoing thermal cross-linking treatment. Although the application technology of artificial esophagus has been greatly improved, the non-degradability of silicone rubber will inevitably cause certain disadvantages in the application of artificial esophagus. At the same time, the strength of naturally extracted collagen is poor, and the degradation rate in the body is very slow Fast, but still can not well meet the needs of body tissue regeneration and repair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The polyurethane raw material is heated to a fluid and then introduced into the injection cylinder, and then die-casted from the injection cylinder into the cavity of the mold by the injection screw, and the polyurethane inner tube is obtained by maintaining pressure and cooling, and simultaneously conducts high-voltage electrostatic discharge treatment. The extracted 0.5% collagen solution was slowly stirred at room temperature for 0.5 hours, then centrifuged at high speed to defoaming, and then 2% chitosan solution was added dropwise to the collagen solution at a volume ratio of 40%, and the mixed solution was placed on a high-speed Homogenize in a stirrer to prepare a collagen-chitosan solution, and perform centrifugal defoaming treatment. The polyurethane inner tube was sleeved on the axis of the polytetrafluoroethylene artificial esophagus mold, and then the collagen-chitosan solution was slowly poured between the polyurethane inner tube and the inner wall of the po...

Embodiment 2

[0019] The polyurethane raw material is heated to a fluid and then introduced into the injection cylinder, and then die-casted from the injection cylinder into the cavity of the mold by the injection screw, and the polyurethane inner tube is obtained by maintaining pressure and cooling, and simultaneously conducts high-voltage electrostatic discharge treatment. The extracted 5% collagen solution was slowly stirred at room temperature for 2 hours, then centrifuged at high speed to defoaming, and then 5% chitosan solution was added dropwise to the collagen solution at a volume ratio of 20%, and the mixed solution was placed on a high-speed Homogenize in a stirrer to prepare a collagen-chitosan solution, and perform centrifugal defoaming treatment. The polyurethane inner tube was sleeved on the axis of the polytetrafluoroethylene artificial esophagus mold, and then the collagen-chitosan solution was slowly poured between the polyurethane inner tube and the inner wall of the polyte...

Embodiment 3

[0021] The polyurethane raw material is heated to a fluid and then introduced into the injection cylinder, and then die-casted from the injection cylinder into the cavity of the mold by the injection screw, and the polyurethane inner tube is obtained by maintaining pressure and cooling, and simultaneously conducts high-voltage electrostatic discharge treatment. The extracted 3% collagen solution was slowly stirred at room temperature for 1 hour, then centrifuged at high speed to defoaming, and then 0.5% chitosan solution was added dropwise to the collagen solution at a volume ratio of 5%, and the mixed solution was placed on a high-speed Homogenize in a stirrer to prepare a collagen-chitosan solution, and perform centrifugal defoaming treatment. The polyurethane inner tube was sleeved on the axis of the polytetrafluoroethylene artificial esophagus mold, and then the collagen-chitosan solution was slowly poured between the polyurethane inner tube and the inner wall of the polyte...

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Abstract

The present invention relates to a degradable composite artificial esophagus made of polyurethane, collagen and chitosan and its preparation method. Said invented artificial esophagus is formed from two layers, its internal layer is an internal tube obtained by using polyurethane material through preparation process and its external layer is made up by using cross-linked collagen-chitosan sponge, then internal tube is covered with the cross-linked collagen-chitosan sponge layer. Its preparation method includes the following steps: firstly, cover-mounting the discharge-treated polyurethane internal tube into the teflon shaft centre, then pouring the centrifugally-defoamed collagen-chitosan solution into the between of polyurethane internal tube and inner wall of teflon cylinder body, standing still to obtain the artificial esophagus mould, finally low-temp. prefreezing said mould, vacuum freeze-drying and making cross-linking treatment. Said antificial esophagus has good biological compatibility.

Description

technical field [0001] The invention relates to a degradable composite artificial esophagus and a preparation method thereof, in particular to a degradable composite artificial esophagus formed with a polyurethane / collagen / chitosan composite material and a preparation method thereof. It belongs to the field of composite materials. Background technique [0002] Most esophageal lesions require resection and esophageal reconstruction. The traditional surgical method replaces the esophagus with autologous organs such as the stomach, jejunum, and colon. Although it can solve the problem of eating, the surgical trauma is large and the anatomy of the digestive tract changes, which brings complications such as digestive physiological dysfunction. In recent years, the rapid development of polymer biomaterials and biomedical engineering has made artificial esophagus possible. The use of artificial materials to reconstruct the esophagus in situ can reduce the surgical trauma, simplif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/04
Inventor 孙康乔秀颖吴人洁高向阳
Owner SHANGHAI JIAO TONG UNIV
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