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circRNA marker for liver cancer diagnosis

A marker, liver cancer technology, applied in the field of biomedicine, to achieve the effect of convenient sampling, accurate diagnosis and easy detection

Inactive Publication Date: 2019-01-08
SHANGHAI TENTH PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report about circRNA_104075 as a new serum tumor marker in liver cancer.

Method used

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  • circRNA marker for liver cancer diagnosis
  • circRNA marker for liver cancer diagnosis
  • circRNA marker for liver cancer diagnosis

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Embodiment

[0040] 1 Materials and methods

[0041] 1.1 Specimen collection

[0042]All specimens were collected in Shanghai Ruijin Hospital from May 2015 to May 2017. The average age of patients with liver cancer is 64.59±5.71 years old, with a male to female ratio of 1.66:1; the average age of hepatitis B patients is 39.75±5.52 years old, with a male to female ratio of 1.3:1; the average age of hepatitis C patients is 57.48±10.21 years old, with a male to female ratio of 1.17: 1. The average age of liver cirrhosis patients is 57.42±8.75 years old, with a male to female ratio of 2.29:1; the average age of colon cancer patients is 62.18±10.44 years old, with a male to female ratio of 3.29:1; the average age of lung cancer patients is 54.43±11.01 years old, with a male to female ratio of 3 :1; average age of gastric cancer patients, 61.25±13.02 years old, male to female ratio 2.8:1; average age of breast cancer patients, 39.73±10.67 years old, all female patients; average age of healthy i...

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Abstract

The invention discloses a circRNA marker for liver cancer diagnosis. The circRNA marker is circ-104075. Experiments prove that circRNA-104075 highly expresses in serum of liver cancer patients, expression of the circRNA-104075 is positively adjusted by HNF4a in liver cancer cells, the circRNA-104075 stimulates YAP expression through adsorbing mir-582-3p, the level of the circ-104075 in the liver cancer patients is higher than normal individuals and other disease patients, and the circ-104075 is high in specificity expression in liver cancer. AUC-ROC analysis proves that the serum circ-104075 is higher in diagnosis efficiency when being compared with other non-coded RNA markers, so that circ-104075 can serve as a novel liver cancer diagnosis marker.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a circRNA marker for the diagnosis of liver cancer. Background technique [0002] Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor in the world, ranking the second and sixth among the leading causes of cancer death in men and women. There are more than 62,000 new cases of HCC each year worldwide. The onset of liver cancer is insidious and the prognosis is poor. Most of them are in the middle and late stage when they see a doctor, and there is a lack of effective radical treatment. Since sorafenib was approved for the first-line treatment of advanced liver cancer in 2007, targeted therapy drugs have brought new hope to patients with advanced liver cancer. However, so far, there are still many problems to be solved, such as sorafenib can only prolong the median survival time of advanced liver cancer by 2-3 months, there are too few genes that can be use...

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 王佳谊张骁郭素素乔永霞孙奋勇潘秋辉吴棋陈岩邾国庆杨月月
Owner SHANGHAI TENTH PEOPLES HOSPITAL
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