Construction method of mouse sinus elevation model based on BIO-OSS bone powder

Abstract

The invention discloses a construction method of a mouse sinus elevation model based on BIO-OSS bone powder. Mouse sinus and paranasal sinus mucosa migrated mutually, nasal bones are long and flat, and nasal cavity anatomy is wide. Mouse sinus lifting model is replaced by mouse nasal bone approach, which is easy to operate, low cost, and beneficial to in-depth study.

Description

technical field [0001] The invention belongs to the technical field of oral implantology, and in particular relates to a method for constructing a mouse sinus cavity lifting model based on BIO-OSS bone powder. Background technique [0002] The problem that often exists in implant restoration of missing maxillary posterior teeth is insufficient bone height available for implant. Maxillary sinus floor elevation (maxillary sinus floor elevation), also known as maxillary sinus augmentation (maxillary sinus augmentation), as an important bone augmentation method, lifts the maxillary sinus mucosa after preparing the implant socket through the alveolar crest , or lift the maxillary sinus mucosa after fenestration from the side wall of the maxilla, implant or not implant bone augmentation material under the raised mucosa, and place implants at the same time or at a later time, as time goes by, the raised submucosal There is new bone formation, which itself forms a new location for ...

AI Technical Summary

Problems solved by technology

[0002] The problem that often exists in implant restoration of missing maxillary posterior teeth is that the bone height available for implant is insufficient

Due to the small anatomical volume of the maxillary sinus cavity and the difficulty of grasping the surgical site, the current research mainly uses large animals represented by beagle dogs, macaques, and miniature pigs. However, the use of these animals for research has the following shortcomings: ① animal purchase And the cost of feeding is high, and the operation process is complicated; ②The cycle of model making, material collection and specimen processing is long; ③The selectivity of supporting reagents and consumables such as antibodies is low, which is not conducive to in-depth exploration of the relevant mechanisms of the process from the perspective of molecular biology; ④Currently based on The gene editing technology of large animals has yet to mature, and the mainstream model animals still use mice as the background, and model animals are the most direct tool for researchers to explore and understand gene functions, and large animals are at a complete disadvantage in this respect

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