Composition containing imatinib and plant polysaccharide

A technology of plant polysaccharide and composition, applied in the field of medicine

Inactive Publication Date: 2019-01-22
黄泳华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In the prior art, there is no technical inspiration for using the combinati

Method used

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  • Composition containing imatinib and plant polysaccharide
  • Composition containing imatinib and plant polysaccharide
  • Composition containing imatinib and plant polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1 comprises the preparation of the capsule of imatinib mesylate and lentinan

[0063] Prescription (according to 100 capsules)

[0064]

[0065] Preparation

[0066] Get the prescribed amount of imatinib mesylate, lentinan, pregelatinized starch and sodium stearyl fumarate, mix them well, fill them into capsules, and pack them separately to obtain 100 capsules.

Embodiment 2

[0067] Embodiment 2 comprises the preparation of the capsule of imatinib mesylate and polyporus polysaccharide

[0068] Prescription (according to 100 tablets)

[0069]

[0070] Preparation

[0071] Take imatinib mesylate, polyporus polysaccharide, pregelatinized starch and sodium stearyl fumarate in the prescribed amount, mix them well, and press them into 100 tablets.

Embodiment 3

[0072] Example 3 Preparation of capsules comprising imatinib mesylate and cucurbit polysaccharide

[0073] prescription

[0074]

[0075] Preparation

[0076] Take the prescribed amount of imatinib mesylate, cucurbit polysaccharide, pregelatinized starch and sodium stearyl fumarate, mix them thoroughly, and pack them separately.

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Abstract

The invention provides a composition containing imatinib or pharmaceutically acceptable salt of imatinib and plant polysaccharide, wherein the plant polysaccharide is selected from one of lentinan, polyporus polysaccharide and lagenaria siceraria polysaccharide. The animal experiment shows that the composition can generate a synergetic antitumor effect for liver cancer, stomach cancer and lung cancer models.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition containing imatinib and plant polysaccharides. Background technique [0002] Imatinib (also known as STI-571, CGP57148B) is a phenylaminopyrimidine derivative with a chemical name of (4-[(4-methyl-1-piperazine)methyl]-N-[ 4-Methyl-3-{(4-(3-pyridine)2-pyrimidine)}amino]phenyl)aniline, its mesylate salt for medicinal purposes, its structural formula is shown below. [0003] [0004] Imatinib is a selective tyrosine kinase inhibitor, which inhibits its tyrosine kinase activity by competitively binding to the ATP-binding site on BCR-ABL kinase, blocking the kinase's autophosphorylation and Substrate phosphorylation level, thereby specifically inhibiting the proliferation of BCR-ABL positive cells and inducing their apoptosis. The FDA-approved indications for imatinib include hematological tumors such as chronic myeloid leukemia (CML) and solid tumors such as gastr...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K31/506A61P35/00
CPCA61K31/506A61K31/715A61P35/00A61K2300/00
Inventor 向飞卢剑飞孙伟光黄泳华
Owner 黄泳华
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