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Novel extraction method of total flavonoids in Senecio scandens

An extraction method, the technology of senecio, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of destroying the active ingredients of senecio, cumbersome extraction process, and reducing work efficiency, so as to avoid long-term reflux extraction and detection process Simplicity and efficiency-enhancing effects

Inactive Publication Date: 2019-01-22
GUIZHOU UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) The current extraction process for total flavonoids is cumbersome and the extraction rate is low
[0006] (2) The traditional pulverizer motor is prone to overheating during extreme pulverization, destroying the active ingredients of Senecio; in addition, it is easy to cause the pulverizer to burn out due to excessive temperature, reducing work efficiency

Method used

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  • Novel extraction method of total flavonoids in Senecio scandens
  • Novel extraction method of total flavonoids in Senecio scandens
  • Novel extraction method of total flavonoids in Senecio scandens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Effect of ethanol concentration on extraction rate

[0059] Divide Senecio powder into 5 parts on average, put them into ethanol solutions with concentrations of 50%, 60%, 70%, 80%, and 90% for soaking respectively, and then extract them ultrasonically at 350W90°C for 40min, and concentrate by suction The content was measured by ultraviolet spectrophotometer respectively, and the test results were as follows: image 3 Shown, the ethanol concentration that the present invention adopts is optimal extraction concentration.

Embodiment 2

[0061] Effect of temperature on extraction rate

[0062] Divide Senecio powder into 5 parts on average, soak in 60% ethanol solution for 1 hour, then ultrasonically extract at 350W, 40°C, 50°C, 60°C, 70°C, 80°C respectively for 40min, and filter and concentrate with ultraviolet light respectively. A spectrophotometer was used to measure the content, and the test results were as follows: Figure 4 As shown, as the temperature increases, the extraction rate of flavonoids increases gradually, and reaches the highest level at 80 ° C. Therefore, the extraction temperature selected by the present invention is the optimum extraction temperature. When the temperature is too high, a large amount of alcohol-soluble impurities The dissolution rate is significantly accelerated, which interferes with the extraction of flavonoids, resulting in a decline in the extraction rate of the same type.

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Abstract

The invention belongs to the technical field of organic substance extraction, and discloses a novel extraction method of total flavonoids in Senecio scandens. The method comprises the steps of conducting cleaning, disinfection, drying and pulverizing on the above part of fresh Senecio scandens root, conducting sieving by a 20 mesh sieve to obtain a Senecio scandens powder; putting the Senecio scandens powder in a 60% ethanol solution, conducting immersing for 1 hour, and conducting ultrasonic extraction for 40 min under conditions of 350 W and 80 DEG C; after ultrasonication, taking out the solution, conducting suction filtration, retaining the filtrate, immersing the filter residue in 70% ethanol for 1 hour and then conducting vacuum suction filtration; merging the two filtrates, conducting centrifugation to obtain a supernatant, conducting concentration to volatilize off remaining ethanol to obtain a flavonoid extract concentrate; and conducting lyophilization to obtain a lyophilizedpowder, that is, the total flavonoids in Senecio scandens. The method of the invention adopts an ultrasonic extraction method to extract total flavonoids in Senecio scandens, the detection process issimple, the extraction rate is high, the extraction speed is fast, and the problem of long-time reflux extraction in a traditional extraction process is avoided.

Description

technical field [0001] The invention belongs to the technical field of organic substance extraction, and in particular relates to a novel extraction method of total flavonoids in Senecio. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: [0003] Senecio is a Compositae herb that grows on hillsides, under sparse forests, in forests, roadsides, and ditch grass. It is cold in nature and bitter in taste. It is mostly used for wind-heat and cold, red eyes, swelling and pain, diarrhea and dysentery, skin eczema and boils. Senecio mostly contains hepatotoxic pyrrolizidine alkaloids, whose acute and chronic poisoning can cause hepatic sinusoidal obstruction syndrome, hepatic macrocytosis or liver fibrosis. Senecio contains a large amount of total flavonoids. Flavonoids have various physiological activities and pharmacological effects such as anti-free radicals, anti-oxidation, anti-cancer, anti-bacterial, anti-virus,...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P39/06A61P35/00A61P31/04A61P31/10A61P31/12A61P29/00A61P37/08A61P3/10G01N21/31G01N1/38
CPCA61K36/28A61K2236/13A61K2236/15A61K2236/17A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P3/10A61P29/00A61P31/04A61P31/10A61P31/12A61P35/00A61P37/08A61P39/06G01N1/38G01N21/31
Inventor 陈燕芹刘红
Owner GUIZHOU UNIV OF ENG SCI
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