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Use of HA-Oligo or salt of HA-Oligo in preparation of medicines for treating miocardial infarction

A technology of oligomeric hyaluronic acid and hyaluronic acid, which can be used in drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc., can solve problems such as no reports of oligomeric hyaluronic acid myocardial infarction, and achieve good clinical application prospects. The effect of promoting myocardial regeneration and promoting proliferation

Active Publication Date: 2019-03-29
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no report on the treatment of myocardial infarction with oligomeric hyaluronic acid and its salts

Method used

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  • Use of HA-Oligo or salt of HA-Oligo in preparation of medicines for treating miocardial infarction
  • Use of HA-Oligo or salt of HA-Oligo in preparation of medicines for treating miocardial infarction
  • Use of HA-Oligo or salt of HA-Oligo in preparation of medicines for treating miocardial infarction

Examples

Experimental program
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Embodiment 1

[0027] Embodiment 1 Preparation of oligomeric hyaluronic acid of the present invention

[0028] Dissolve 100 mg of h-HA with a molecular weight of 1 million in 50 mL of 0.1 M sodium acetate buffer (pH 5.4), add 20,000 activity units of bovine testicular hyaluronidase, and incubate at 37°C for 8 hours. 10 mL of the solution was removed and 1 mL of 100% trifluoroacetic acid (TCA) was added to neutralize the hyaluronidase. The resulting enzyme precipitate was removed by centrifugation. The supernatant was collected and dialyzed in a dialysis bag with a molecular weight of 1000 Da at 4°C for 72 hours, and the water was changed at least 6 times in the middle. The liquid in the dialysis bag was collected, and the dialysis was continued for 72 hours at 4° C. in a dialysis bag with a molecular weight of 5000 Da. After the dialysis, the outer aqueous phase was collected and freeze-dried, and the freeze-dried o-HA sample was stored at 4°C for future use.

[0029] The molecular weight...

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Abstract

The invention discloses a use of HA-Oligo or salt of HA-Oligo in preparation of medicines for treating miocardial infarction. The HA-Oligo and salt of HA-Oligo disclosed by the invention can effectively treat the miocardial infarction and is significant in treatment effects, a new medicine for clinical treatment of the miocardial infarction is provided, and the clinical application prospects are good.

Description

technical field [0001] The present invention relates to the application of oligomeric hyaluronic acid or its salt in the preparation of medicine for treating myocardial infarction. Background technique [0002] Myocardial infarction, also known as myocardial infarction, refers to myocardial necrosis caused by acute and persistent ischemia and hypoxia (coronary insufficiency); refers to the interruption of coronary blood on the basis of coronary artery disease, causing the corresponding myocardial Severe and persistent acute ischemia will eventually lead to ischemic necrosis of the myocardium; patients with acute myocardial infarction often have persistent severe retrosternal pain, fever, increased white blood cell count, elevated serum myocardial enzymes, and electrocardiogram Reflects a series of characteristic evolutions of acute myocardial injury, ischemia and necrosis, and may appear arrhythmia, shock and heart failure, is a severe type of coronary heart disease, may be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/728A61P9/10
CPCA61K31/728A61P9/10
Inventor 巩长旸吴秦洁王宁
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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