Anti-tumor vaccine compound, preparation method, injection and application

An anti-tumor and complex technology, applied in the field of anti-tumor, can solve the problems of low activation efficiency, inaccuracy, high price, etc., and achieve the effects of convenient large-scale production, simple preparation process and good biological safety.

Active Publication Date: 2019-04-05
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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Problems solved by technology

[0006] In order to solve the above problems, the present invention provides an anti-tumor vaccine compound and its preparation method, injection and application, which solves the problems of poor curative effect, low activation efficiency, imprecise activation, few antigens, and high price of existing vaccines.

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  • Anti-tumor vaccine compound, preparation method, injection and application
  • Anti-tumor vaccine compound, preparation method, injection and application
  • Anti-tumor vaccine compound, preparation method, injection and application

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Embodiment Construction

[0037] The principles and features of the present invention are described below in conjunction with examples, which are only used to explain the present invention and are not intended to limit the scope of the present invention.

[0038] An anti-tumor vaccine complex prepared by physical mixing of ROS-rich cell microvesicles and immune activators.

[0039] The active oxygen content in the ROS-rich cellular microvesicles is not lower than the intracellular active oxygen content.

[0040] The particle size of the ROS-rich cell microvesicles is 100-1000 nanometers.

[0041] A preparation method of anti-tumor vaccine complex, comprising the following steps:

[0042] 1): Obtain fresh tumor tissue and culture primary tumor cells to obtain primary tumor cells;

[0043] 2): Use X-ray or electron ray to irradiate primary tumor cells to enrich ROS in tumor cells and secrete microvesicles containing high concentration of ROS;

[0044] 3): collecting tumor cell microvesicles containing...

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Abstract

The invention provides an anti-tumor vaccine compound which is prepared by physically mixing ROS-rich cell microvesicle and immune activating agent. The invention provides a preparation method for theanti-tumor vaccine compound. The invention provides an anti-tumor vaccine compound injection. The invention provides an application of the anti-tumor vaccine compound. The anti-tumor vaccine compoundis applied to tumors, such as lung cancer, breast cancer, glioma, ovarian cancer, gastric cancer, colorectal cancer, osteogenic sarcoma, prostatic cancer, cervical cancer, malignant pleural effusionor melanoma. According to the invention, the problems of low immune activation efficiency, inaccuracy and few antigens of the present vaccine can be solved.

Description

technical field [0001] The present invention relates to the field of anti-tumor, more particularly, relates to an anti-tumor vaccine compound and its preparation method, injection and application. Background technique [0002] Chemotherapy, radiotherapy, and targeted therapy are conventional treatments for tumors, but their overall therapeutic effect is limited, and drug resistance or treatment resistance is prone to occur. Malignant tumors often have the biological characteristics of invasiveness and relapse, and there is an extremely complex immunosuppressive microenvironment in the tumor tissue. Therefore, it is necessary to design individuals with stronger targeting, less toxic side effects, and improved immune microenvironment Chemotherapy program. With the rapid development of tumor genomics and immunology, immunotherapy has become the most potential tumor treatment. Because tumor cells contain tumor antigens, the body's immune system can distinguish tumor cells from...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00A61P35/00
CPCA61K9/0019A61K39/0011A61K2039/55505A61K2039/55561A61P35/00
Inventor 金红林杨坤禹万超孙亚洁张玲玲
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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