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A kind of antitumor vaccine compound and preparation method, injection and application

A complex and anti-tumor technology, applied in the field of anti-tumor, can solve the problems of inaccuracy, low activation efficiency, and high price, and achieve the effects of simple preparation process, convenient large-scale production, and good biological safety

Active Publication Date: 2020-06-12
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the above problems, the present invention provides an anti-tumor vaccine compound and its preparation method, injection and application, which solves the problems of poor curative effect, low activation efficiency, imprecise activation, few antigens, and high price of existing vaccines.

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  • A kind of antitumor vaccine compound and preparation method, injection and application
  • A kind of antitumor vaccine compound and preparation method, injection and application
  • A kind of antitumor vaccine compound and preparation method, injection and application

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Embodiment Construction

[0036] The principles and features of the present invention are described below in conjunction with examples, which are only used to explain the present invention and are not intended to limit the scope of the present invention.

[0037] An anti-tumor vaccine complex is prepared by physical mixing of ROS-rich cell microbubble solution and immune activator. The content of ROS in cell microvesicles is 50-500 times that of normal cells.

[0038] The concentration of the immune adjuvant in the anti-tumor vaccine complex is 300 μg / mL.

[0039] The oxygen carrying capacity of the cell microbubbles is not lower than the active oxygen content in the cells.

[0040] The immune activator is CpG or Freund's adjuvant.

[0041] An anti-tumor vaccine compound, the preparation method of the ROS-rich cell microvesicles comprises the following steps:

[0042] 1): Obtain fresh tumor tissue and culture primary tumor cells to obtain primary tumor cells;

[0043] 2): Radiation is used to irrad...

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Abstract

The invention provides an anti-tumor vaccine complex, which is prepared by physically mixing ROS-rich cell microvesicles and immune activators. The anti-tumor vaccine complex provided by the invention can be prepared into injections. The anti-tumor vaccine compound provided by the invention can be applied to lung cancer, breast cancer, glioma, ovarian cancer, gastric cancer, colorectal cancer, osteosarcoma, prostate cancer, cervical cancer, malignant pleural effusion or melanoma, etc. tumor. The invention can solve the problems of low immune activation efficiency, inaccuracy and few antigens of existing vaccines.

Description

technical field [0001] The present invention relates to the field of anti-tumor, more particularly, relates to an anti-tumor vaccine compound and its preparation method, injection and application. Background technique [0002] Chemotherapy, radiotherapy, and targeted therapy are conventional treatments for tumors, but their overall therapeutic effect is limited, and drug resistance or treatment resistance is prone to occur. Malignant tumors often have the biological characteristics of invasiveness and relapse, and there is an extremely complex immunosuppressive microenvironment in the tumor tissue. Therefore, it is necessary to design individuals with stronger targeting, less toxic side effects, and improved immune microenvironment Chemotherapy program. With the rapid development of tumor genomics and immunology, immunotherapy has become the most potential tumor treatment. Because tumor cells contain tumor antigens, the body's immune system can distinguish tumor cells from...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/00A61P35/00
CPCA61K9/0019A61K39/0011A61K2039/55505A61K2039/55561A61P35/00
Inventor 金红林杨坤禹万超孙亚洁张玲玲
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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