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Nano drug-loading compound for targeted diagnosis and treatment of arteriosclerosis and preparation method thereof

A nano-drug-loading and arteriosclerosis technology, which is applied in the fields of polymer materials and medical engineering, can solve the problems of reducing the binding force between nano-carriers and atherosclerosis, difficulty in early diagnosis, etc., achieve wide application prospects, improve long-term circulation and accumulation effect of action

Inactive Publication Date: 2019-04-16
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows researchers to combine diagnostic agents (chemo) or therapy tools into one molecule called an organic compound. These compositions are designed specifically for use in treatments such as angiography and cancer prevention. They also contain magnetic iron oxides (MFe), allowing them to carry their own medicine without being affected by other substances like water vapor. Overall, this new approach makes delivering and maintaining effective medications more efficient while reducing patient's risk of side effects from these chemicals.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving understanding how blood vessels develop from damage caused by various factors like smoking, obesity, diabetes mellitus (DM), stroke, cancer, and chronotropic hemorrhage into better ways to identify patients at risk while reducing complications associated with these conditions through effective treatments.

Method used

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  • Nano drug-loading compound for targeted diagnosis and treatment of arteriosclerosis and preparation method thereof
  • Nano drug-loading compound for targeted diagnosis and treatment of arteriosclerosis and preparation method thereof
  • Nano drug-loading compound for targeted diagnosis and treatment of arteriosclerosis and preparation method thereof

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preparation example Construction

[0025] The present invention provides a method for preparing a nano drug-loaded complex for targeted diagnosis and treatment of arteriosclerosis, which comprises the following steps:

[0026] S1) Dissolve and mix superparamagnetic ferrite nanoparticles, polylactic acid-glycolic acid / polyethylene glycol copolymer and blood lipid-lowering drug, ultrasonically disperse, vacuum rotary evaporation until the solvent evaporates; after cooling to room temperature, perform ultrasonic Disperse, filter, centrifuge to remove the precipitate, and freeze-dry the upper black transparent aqueous solution to obtain a powdery solid. The powdery solid has a core-shell structure. Formed from hydrophilic polyethylene glycol carboxylic acid segments, hydrophobic superparamagnetic ferrite nanoparticles and blood lipid-lowering drugs are encapsulated in the inner core layer; the polylactic acid-glycolic acid / polyethylene glycol copolymer is composed of Carboxyl-terminated polylactic acid-glycolic aci...

Embodiment 1

[0037] This embodiment provides a preparation method for superparamagnetic ferrite magnetic nanoparticles, which includes the following steps: 2mmol iron triacetylacetonate, 0.6mmol manganese acetylacetonate, 0.4mmol zinc acetylacetonate and 10mmol 1,2-hexadecanediol Mix in a reaction vessel, then add 3mmol oleic acid and 3mmol oleylamine respectively, and add 10mL dibenzyl ether, stir magnetically under the protection of argon, heat to 200°C for 2h, then heat to 300°C for 0.5h under reflux; After cooling to room temperature, add 40mL ethanol to the reaction product, centrifuge at 8000rpm for 10min to remove the filtrate; add 0.05mL oleic acid and 0.05mL oleamide to the brown-black precipitate, dissolve and disperse the precipitate with n-hexane, and centrifuge at 8000rpm for 10min to remove Impurities, the filtrate is repeatedly centrifuged in ethanol to remove the filtrate, and finally dispersed in n-hexane for storage; the particle diameter of the superparamagnetic ferrite n...

Embodiment 2

[0039] This embodiment provides the preparation method of polylactic acid-glycolic acid / polyethylene glycol copolymer, which comprises the following steps: dissolving carboxyl-terminated polylactic acid-glycolic acid copolymer in 20mL of dichloromethane, adding N-hydroxysuccinyl Amine (NHS), dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP), stirred magnetically under nitrogen; washed with ice methanol three times after overnight at room temperature, dried in vacuo and dissolved in 20 mL of dichloro In methane, under the protection of nitrogen, add aminopolyethylene glycol carboxyl dichloromethane solution dropwise, react at room temperature for 48 hours, wash with excess glacial ether three times, and vacuum dry at room temperature for 24 hours.

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Abstract

The invention discloses a nano drug-loading compound for targeted diagnosis and treatment of arteriosclerosis and a preparation method thereof. The method includes first preparing polylactic acid-glycolic acid/polyethylene glycol copolymer (PLGA-PEG-COOH), and then assembling superparamagnetic ferrite nanoparticles (SPIO) with PLGA-PEG-COOH by hydrophobic electrostatic interaction, adsorbing a hypolipidemic drug with the inner core and finally modifying VCAM-1 targeting peptide on the hydrophilic surfaces of micelles. The VCAM-1 targeting peptide which can target vascular cell adhesion molecules in the arteriosclerotic lesion part is provided as a target to construct an integrated therapeutic reagent capable of targeting the arteriosclerosis.

Description

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Claims

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Application Information

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Owner BEOGENE BIOTECH GUANGZHOU
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