Zif-8 coated ferric oxide nanoparticle material and its preparation method and application

A technology of ZIF-8 and ferric oxide, which is applied in the direction of nano-medicine, nanotechnology, nanotechnology, etc., to achieve the effects of improved diagnosis, low cost and simple synthesis process

Active Publication Date: 2021-10-22
SHANGHAI NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Iron with 5 unpaired electrons (Fe 3+ ) ions increase the r 1 value, but the high r of iron oxide nanoparticles due to the intrinsic high magnetic moment 2 prevents them from being used as T 1 contrast agent

Method used

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  • Zif-8 coated ferric oxide nanoparticle material and its preparation method and application
  • Zif-8 coated ferric oxide nanoparticle material and its preparation method and application
  • Zif-8 coated ferric oxide nanoparticle material and its preparation method and application

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preparation example Construction

[0059] The preparation method of described ZIF-8 coating iron ferric oxide nano particle material comprises the following steps

[0060] (1) Water-soluble Fe 3 o 4 The nanoparticles are dissolved in water to obtain Fe 3 o 4 aqueous solution,

[0061] (2) Disperse 2-methylimidazole and polyvinylpyrrolidone in Fe 3 o 4 dissolved in an aqueous solution, and stirred at room temperature to obtain a mixed solution;

[0062] (3) Pour the aqueous solution of zinc nitrate hexahydrate into the mixed solution quickly, and continue to stir;

[0063] (4) centrifuging, washing, and collecting particles to obtain ZIF-8 coated ferric oxide nanoparticle material.

[0064] Preferably:

[0065] The 2-methylimidazole, polyvinylpyrrolidone, water-soluble Fe 3 o 4 The dosage ratio of the nanoparticles and the zinc nitrate hexahydrate is 400-450mg:10-30mg:5-15mg:20-30mg.

[0066] Among them, 2-methylimidazole (ligand) and zinc nitrate hexahydrate (central ion) form ZIF-8 through coordinat...

Embodiment 1

[0094] A kind of ZIF-8 is coated with ferric oxide nanoparticle material, by will have T 1 Weighted MRI effect of Fe 3 o 4 The nanoparticles were embedded in ZIF-8, resulting in T 2 Weighted MRI effect of ZIF-8 coated Fe3O4 nanoparticle material.

[0095] ZIF-8 of the present embodiment is coated with ferric oxide nano particle material preparation method as follows:

[0096] (1) Oil-soluble Fe 3 o 4 The preparation method, its steps are as follows:

[0097] First, oil-soluble Fe3O4 was prepared by high-temperature pyrolysis: in a three-necked flask, N 2 Under the atmosphere, slowly heat 30mL oleylamine to 300°C, then inject a mixed solution of 1mmol iron acetylacetonate, 4mL N-methylpyrrolidone and 6mL oleylamine into the three-necked bottle, then continue heating, stop heating and continue stirring until Cool to room temperature. Transfer to a centrifuge tube, add ethanol, 10000r, 10min, discard the supernatant; dissolve with n-hexane, add ethanol, 12000r, 8min, disc...

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Abstract

The present invention relates to a kind of ZIF-8 coating iron ferric oxide nano particle material and its preparation method and application, by having T 1 Weighted MRI effect of Fe 3 o 4 Nanoparticles are embedded in ZIF‑8, resulting in T 2 Weighted MRI effect of ZIF‑8 coated Fe3O4 nanoparticle material, which was prepared by high temperature pyrolysis to synthesize oil-soluble Fe 3 o 4 , using the method of ligand exchange for oil-soluble Fe 3 o 4 , to prepare water-soluble Fe 3 o 4 Nanoparticles, ZIF‑8-coated Fe3O4 nanoparticles were synthesized using a one-pot synthesis method. Compared with the prior art, the preparation method of the present invention is simple, and the water-soluble Fe 3 o 4 Nanoparticles can be used as T 1 Contrast agent, Fe 3 o 4 @ZIF‑8 as T 2 Contrast agent, in tumor, Fe 3 o 4 @ZIF‑8 responds to weak acid and GSH, resulting in a shift in MRI contrast, which can improve the diagnosis of tumors.

Description

technical field [0001] The invention relates to the technical fields of inorganic nanomaterials and molecular imaging, in particular to a ZIF-8 coated ferric oxide nanoparticle material and its preparation method and application. Background technique [0002] Magnetic resonance imaging (MRI) is one of the most powerful diagnostic tools for spatial resolution of water protons in vivo by detecting the relaxation signal of (water) proton spins in a strong magnetic field excited by radiofrequency waves and using magnetic gradients. It has attracted much attention due to its noninvasiveness, submillimeter spatial resolution, high anatomical contrast, and excellent soft tissue differentiation ability. However, the images obtained by MRI are often insufficient to distinguish normal tissue from damage, so contrast agents that enhance the contrast between the lesion and the background are needed to improve the sensitivity of MRI. Contrast agents can be divided into two categories, p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/10A61K49/18B82Y5/00B82Y40/00
CPCA61K49/08A61K49/10A61K49/183A61K49/1833B82Y5/00B82Y40/00
Inventor 林焦敏辛朋燕杨仕平田启威安璐蒋文倩
Owner SHANGHAI NORMAL UNIVERSITY
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